Background: Ewing sarcoma is one of the most frequent soft-tissue tumors in
pediatric patients. The current treatment protocols recommend stem cell apheresis (SCA) after completion of the second course of induction therapy with
vincristine, ifosfamide, doxorubicine, and etoposide (VIDE). The feasibility of
SCA and graft compositions in adult patients with Ewing sarcoma have not
been previously analyzed.
Methods and Materials: The authors analyzed 29 stem cell collections of
19 adult patients (9 male, 10 female) at a median age of 27 (range 19–53) years
mobilized after VIDE (n = 17), cyclophosphamide/topotecan (n = 1) or
vincristine, dactinomycin and ifosfamide (n = 1) chemotherapy. All patients
were mobilized with filgrastim 5 μg/kg twice daily from day +7 of chemotherapy. The collections were performed if CD34+ cell count in peripheral blood
was >10/μL. The target yields were ≥4106 CD34+ cells/kg body weight.
Results: Median CD34+ cells/μL in peripheral blood before SCA were 45.8
(range 6.7–614.4)/μL. The median cumulative yields were 10.6 (range 1.5–38.8)
CD34+ cells/kg body weight and ≥2106 in all but two patients (89%). CD34,
CD3, and CD56 yields in collections after the third VIDE and after later
courses did not differ. Four patients underwent high-dose therapy with
autologous transplantation, and all were engrafted.
Discussion: Stem cell mobilization is feasible in most Ewing sarcoma patients.
Additionally, the present study's data suggest that it is safe to postpone stem
cell collection to a later VIDE chemotherapy cycle if medically indicated
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:88854 |
| Date | 04 January 2024 |
| Creators | Franke, Georg-Nikolaus, Pfannes, Roald, Heyn, Simone, Brückner, Mandy, Rieprecht, Susanne, Bach, Enrica, Remane, Yvonne, Leiblein, Sabine, Pönisch, Wolfram, Niederwieser, Dietger, Schwind, Sebastian, Platzbecker, Uwe, Jentzsch, Madlen, Vucinic, Vladan |
| Publisher | Wiley |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
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