The discovery of insulin in 1921 has been one of greatest scientific achievements of the 20th century. Since then, the availability of insulin has shifted the focus of diabetes treatment from trying to keep patients alive to saving and improving the life of millions. Throughout this time, basic and clinical research has advanced our understanding of insulin synthesis and action, both in healthy and pathological conditions. Yet, multiple aspects of insulin production remain unknown. In this review, we focus on the most recent findings on insulin synthesis, highlighting their relevance in diabetes.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:73397 |
| Date | 20 January 2021 |
| Creators | Vasiljevic, Jovana, Torkko, Juha M., Knoch, Klaus-Peter, Solimena, Michele |
| Publisher | Diabetologia |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | German |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1432-0428, 10.1007/s00125-020-05192-7, info:eu-repo/grantAgreement/European Commission/H2020 | IMI2-RIA/115881//Assessing risk and progression of prediabetes and type 2 diabetes to enable disease modification/RHAPSODY, info:eu-repo/grantAgreement/European Commission/H2020 | IMI2-RIA/115797//Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes/INNODIA |
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