Siliciumhaltige Analoga von Loperamid und Penfluridol wurden hergestellt, Versuche zu einer alternativen Synthese von Sila-Haloperidol wurden unternommen. Siliciumhaltige Sigma-Liganden des 1,4´-Silaspiro[tetralin-1,4´-piperidin]-Typs wurden hergestellt und kristallographisch sowie pharmakologisch mit ihren Kohlenstoff-Analoga verglichen. / Silicon-containing analogs of loperamide and penfluridol were synthesized, an alternative synthesis of sila-haloperidol was tried. Silicon-containing sigma ligands of the 1,4´-silaspiro[tetralin-1,4´-piperidinium] type were synthesized and their x-ray structures as well as their pharmacological properties were compared with their respective carbon analogs.
| Identifer | oai:union.ndltd.org:uni-wuerzburg.de/oai:opus.bibliothek.uni-wuerzburg.de:2296 |
| Date | January 2007 |
| Creators | Müller, Barbara |
| Source Sets | University of Würzburg |
| Language | deu |
| Detected Language | English |
| Type | doctoralthesis, doc-type:doctoralThesis |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
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