Cardiovascular disease is the leading cause of mortality in diabetic patients, and diabetes is one of the main causes of cardiovascular disease. Risk factors for cardiovascular disease result in structural and functional changes in the vascular wall. Arterial stiffness is a prominent structural change observed in the arterial wall that can be measured in clinical settings. The purpose of this thesis was to create a static model of the changes in arterial stiffness seen in diabetes. Elastic tubes with varying wall thicknesses were used to create artificial arteries for this purpose. Compliance (inverse of stiffness) of the arteries was determined using a pressurevolume model and a mathematical model. The compliance curves generated using the pressurevolume model exhibited trends predicted by the mathematical model. These trends were comparable to arterial stiffness changes seen in diabetes. Compliance obtained from pressurevolume measurements of elastic tubes with varying wall thickness can therefore be used to model the general trends of arterial stiffness in diabetes.
| Identifer | oai:union.ndltd.org:CALPOLY/oai:digitalcommons.calpoly.edu:theses-4310 |
| Date | 01 June 2023 |
| Creators | Skattenborg, Andrea |
| Publisher | DigitalCommons@CalPoly |
| Source Sets | California Polytechnic State University |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | Master's Theses |
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