Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells

Description

Yes / The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed. / Daisy Appeal Charity (Grant: DAhul0211), the University of Hull scholarship, Newcastle University, EPSRC and High Force Research Ltd, EPSRC Fellowship (EP/G005206/1)

Links & Downloads

1. Nigam S, Burke BP, Davies LH et al (2016) Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells. Chemical Communications. 52(44): 7114-7117.
2. http://hdl.handle.net/10454/17281
3. https://doi.org/10.1039/C5CC08325G

Tags

BODIPY

Imaging

Cancer

Additional Fields

Identifer	oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/17281
Date	17 September 2019
Source Sets	Bradford Scholars
Language	English
Detected Language	English
Type	Article, Published version
Rights	(c) 2016 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/3.0/), CC-BY