No / Summary We have produced paediatric reference data for
forearm sites using the Stratec XCT-2000 peripheral
quantitative computed tomography scanner. These data are
intended for clinical and research use and will assist in the
interpretation of bone mineral density and bone geometric
parameters at the distal and mid-shaft radius in children and
young adults aged between 6–19 years.
Introduction Peripheral quantitative computed tomography
(pQCT) provides measurements of bone mineral content
(BMC), density (BMD) and bone geometry. There is a lack
of reference data available for the interpretation of pQCT
measurements in children and young adults. The aim of this
study was to provide reference data at the distal and midshaft
radius.
Methods pQCT was used to measure the 4% and 50% sites
of the non-dominant radius in a cohort of healthy white
Caucasian children and young adults aged between 5 and
25 years. The lambda, mu, sigma (LMS) technique was used
to produce gender-specific reference centile curves and LMS
tables for calculating individual standard deviations scores.
Results The study population consisted of 629 participants
(380 males). Reference centile curves were produced; total
and trabecular BMD for age (distal radius) and for age and
height, bone area (distal and mid-shaft radius), cortical area,
cortical thickness, BMC, axial moment of inertia, stress–
strain index and muscle area (mid-shaft radius).
Conclusions We present gender-specific databases for the
assessment of the distal and mid-shaft radius by pQCT.
These data can be used as control data for research studies
and allow the clinical interpretation of pQCT measurements
in children and young adults by age and height. / Central Manchester and Manchester Children’s University Hospital NHS Research Endowment Fund and the support of the National Osteoporosis Society (Camerton, Bath, UK), which awarded Rebecca Ashby a Linda Edwards Memorial Studentship in 2003 and funded the initial part of the study (1997–1998).
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/14542 |
| Date | 06 December 2008 |
| Creators | Ashby, R.L., Ward, K.A., Roberts, S.A., Edwards, Lisa, Mughal, M.Z., Adams, Jenny E. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, No full-text in the repository |
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