A computational fluid dynamics (CFD) model is developed for pulsatile flows and particle transport to evaluate the possible thrombus trajectory in the feline aorta for Hypertrophic Cardiomyopathy (HCM) heart conditions. An iterative target mass flow rate boundary condition is developed, and turbulent simulations with Lagrangian particle transport model are performed using up to 11M grids. The model is validated for human abdominal aorta flow, for which the results agree within 11.6% of the experimental data. The model is applied for flow predictions in a generalized feline aorta for healthy and HCM heart conditions. Results show that in the HCM case, the flow through the iliac arteries decreases by 50%, due to the large recirculation regions in the abdominal aorta compared to the healthy heart case. The flow recirculation also result in stronger vortices with slower decay, causing entrapment of particles in the thoracic aorta and trifurcation regions.
| Identifer | oai:union.ndltd.org:MSSTATE/oai:scholarsjunction.msstate.edu:td-5796 |
| Date | 12 August 2016 |
| Creators | Borse, Manish Rajendra |
| Publisher | Scholars Junction |
| Source Sets | Mississippi State University |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | Theses and Dissertations |
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