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Previous issue date: 2008-08-29 / INTRODUCTION: The cervical cancer is the third most frequent malignant neoplasia among women in Brazil and it is responsible for the fourth cause of death for cancer. It is related among other causes to persistent infection by human papillomavirus. Doubts persist if HPV type could influence the tumor prognosis. OBJECTIVE: To study the prevalence of HPV 18 and HPV 16 in women presenting cervical cancer in clinic stage Ib, treated by radical hysterectomy with linfadenectomy, establishing prognostic correlation. METHODS: A retrospective cohort study, including 86 pacients with cervical cancer Ec I, submitted to radical hysterectomy, in a single center, in which were analysed the known prognostic factors and the positivity to HPV by PCR. Univariate analysis was performed, with Kaplan-Meir curves, for survival estimative. RESULTS: The prevalence of HPV 16 infection was 65.3% and HPV 18 prevalence was 33.3%. To both virus the prevalence was 26.9%. The overall survival for women presenting HPV 18 infection, in sixty months, was 91% and those women without HPV 18 infection, the overall survival was 96%. The overall survival for women with and without HPV16 infection was 94% and 96%, respectively. The disease free survival was not influenced by the presence of either virus. CONCLUSION: In the present study, in spite of the high prevalence of HPV 18 and HPV 16, the presence of these tipes of HPV have not influenced the prognosis of EcI cervixl cancer in women submitted to radical histerectomy. / INTRODUÇÃO: O câncer do colo uterino é a terceira neoplasia maligna mais frequente entre as mulheres no Brasil e entre elas é responsável pela quarta causa de morte por câncer. Está relacionado, entre outras causas, à infecção persistente pelo papilomavirus humano. Persistem dúvidas se o tipo de HPV exerce influência sobre o prognóstico da doença. OBJETIVO: Estudar a prevalência do HPV 18 e HPV 16 em mulheres com o câncer do colo uterino no estádio clínico Ib, tratadas por histerectomia radical com linfadenectomia pélvica, procurando estabelecer correlação prognóstica. MÉTODOS: Estudo de coorte retrospectivo, incluindo 86 pacientes com câncer do colo uterino Ec I, submetidas à histerectomia radical, em um único centro, no qual foram analisados os fatores prognósticos já conhecidos, além da presença do HPV 16 e 18, pesquisado por PCR. Utilizou-se análise univariada, com curvas de Kaplan-Meir, para estimativa de sobrevida. RESULTADOS: A prevalência do HPV 16 no grupo estudado foi de 65,3% e a prevalência do HPV 18 foi de 33,3%. A prevalência dos casos em que houve infecção por ambos os vírus foi de 26,9%. A sobrevida global para as mulheres portadoras do HPV 18, aos sessenta meses, foi de 91% e nas que não eram portadoras desse vírus foi de 96% (NS). Já para as mulheres portadoras do HPV 16 a sobrevida global foi de 94% e para as não portadoras desse vírus a sobrevida foi 96% (NS). A sobrevida livre de doença também não foi influenciada pela presença do HPV 18 e do HPV 16. CONCLUSÃO: No presente estudo, apesar da alta prevalência do HPV 18 e do HPV 16, a presença desses tipos de HPV não influenciaram o prognóstico das pacientes portadoras de câncer de colo uterino, Ec I, submetidas à histerectomia radical.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.bc.ufg.br:tede/3217 |
| Date | 29 August 2008 |
| Creators | Zampronha, Rossana de Araújo Catão |
| Contributors | Freitas Jr, Ruffo, Murta, Eddie Fernando Cândido |
| Publisher | Universidade Federal de Goiás, Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP), UFG, Brasil, Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | Portuguese |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFG, instname:Universidade Federal de Goiás, instacron:UFG |
| Rights | http://creativecommons.org/licenses/by-nc-nd/4.0/, info:eu-repo/semantics/openAccess |
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