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The role of mononuclear cells in tuberculosis

Thesis presented in fulfilment of the requirements governing the degree of Philosophy in the School of Medicine, University of the Witwatersrand. Johannesburg / Sonicates derived from Mycobacterium tuberculosis suppressed lymphocytes proliferation. Pulsing of monocytes with mycobacterial sonicates resulted in the release of high molecular weight lipids. Both these lipids and those prepared by column fractionation of mycobacterial sonicates suppressed lymphocyte blastogenesis.This effect was due to the activation and not the proliferation of CD8+ lymphocytes by the lipid containing mycobacterial fractions of Mr>200kDa that could be obtained in vitro by column fractions. / IT2018

Identiferoai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/25840
Date03 June 1992
CreatorsSussman, Garth
Source SetsSouth African National ETD Portal
LanguageEnglish
Detected LanguageEnglish
TypeThesis
Formatapplication/pdf

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