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Previous issue date: 2014-06-06 / Introdu??o: A S?ndrome dos ov?rios polic?sticos (SOP) ? uma das endocrinopatias mais comuns em mulheres em idade reprodutiva, e al?m das caracter?sticas cl?ssicas (irregularidade menstrual, anovula??o cr?nica, infertilidade e hiperandrogenismo), est? associada a aspectos da s?ndrome metab?lica (SM), como obesidade e resist?ncia ? insulina. O grau de obesidade determina n?veis diferentes de inflama??o, aumentando citocinas participantes de fun??es metab?licas e end?crinas, al?m de modular a resposta imunol?gica. Altera??es metab?licas, somada ao desequil?brio dos horm?nios sexuais subjacentes ? menstrua??o irregular vistas na SOP podem desencadear processos al?rgicos e a eleva??o de anticorpos IgE totais e espec?ficos indicam que um processo de sensibiliza??o foi iniciado. Objetivo: Avaliar a influ?ncia da SOP sobre par?metros bioqu?micos e n?veis de IgEs total e espec?ficas para aeroal?rgenos em mulheres obesas. Metodologia: Ap?s aprova??o pelo Comit? de ?tica em Pesquisa, foram recrutadas 80 volunt?rias com IMC ? 30 kg/m 2 e idade entre 18 e 45 anos. Dentre estas, 40 portadoras SOP, segundo os crit?rios de Rotterdam e 40 n?o portadoras de SOP (grupo controle). Todas foram analisadas quanto aos par?metros antropom?tricos, cl?nicos, ginecol?gicos, entrevistadas utilizando-se question?rio e submetidas ? coleta de sangue para realiza??o de exames laboratoriais de bioqu?mica cl?nica: colesterol total, LDLcolesterol, HDL-colesterol, triglicer?deos, glicemia de jejum, ur?ia, creatinina, aspartato aminotransferase (AST), alanina aminotransferase (ALT) e imunol?gicos: IgE total e espec?ficas para Dermatophagoides pteronyssinus, Blomia tropicalis, Dermatophagoides farinae e Dermatophagoides microceras. A an?lise estat?stica foi realizada atrav?s do software SPSS 15,0 por meio dos testes Qui-Quadrado, Fisher, teste T de Student e Regress?o log?stica bin?ria, com n?vel de signific?ncia (p<0,05). Resultados: Observou-se no grupo das obesas com SOP que 29 (72,5%)apresentaram ciclo menstrual vari?vel e 27 (67,5%) tiveram dificuldade de engravidar. Quanto ? rela??o cintura-quadril, maior m?dia tamb?m foi verificada nas obesas com SOP (0,87). Concentra??es s?ricas de HDL (36,9 mg/dL) e de ALT (29,3 U/L) apresentaram-se anormais nas obesas com SOP, com rela??o estatisticamente significante . Na an?lise da IgEs total e espec?fica para D. pteronyssinus, resultados elevados tamb?m foram predominantes nas obesas com SOP, com concentra??o s?rica de (365,22 UI/mL) e (6,83 KU/L), respectivamente, tamb?m estatisticamente significantes. Conclus?es: Os resultados enfatizam a import?ncia das an?lises bioqu?micas e dos n?veis de IgEs total e espec?ficas no acompanhamento de anormalidades metab?licas da SOP, que podem influenciar na sensibiliza??o al?rgica em obesas. / Introduction: Polycystic ovary syndrome (PCOS) whose classic features (menstrual irregularity of
oligo/ amenorrhea type, chronic anovulation, infertility and hyperandrogenism clinical and/ or
biochemical), is associated with aspects of metabolic syndrome (MS), as obesity and insulin
resistance. The level of obesity determines different levels of inflammation, increasing cytokines
participants of metabolic and endocrine functions, beyond modulate the immune response. Metabolic
changes, added to the imbalance of sex hormones underlying irregular menstruation observed in
(PCOS) can trigger allergic processes and elevation of total and specific IgE antibodies indicate that
a sensitization process was started. Objective: To evaluate the influence of PCOS on biochemical
parameters and levels of total and specific IgE to aeroallergens in obese women. Methods: After
approval by the Committee of Ethics in Research, were recruited 80 volunteers with BMI ? 30 kg/m2
and age between 18 and 45 years. Among these, 40 with PCOS according to the Rotterdam criteria
and 40 women without PCOS (control group). All participants were analysed with regard to
anthropometric, clinical, gynecological parameters, interviewed using a questionnaire, and
underwent blood sampling for realization of laboratory tests of clinical biochemistry: Total
cholesterol, LDL-cholesterol, HDL- cholesterol, Triglycerides, Fasting glucose, Urea, Creatinine,
Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and immunological: total and
specific IgE to Dermatophagoides pteronyssinus, Blomia tropicalis, Dermatophagoides farinae and
Dermatophagoides microceras.Statistical analysis was performed using SPSS 15.0 software through
the chi-square tests, Fisher, Student t test and binary logistic regression, with significance level (p
<0.05). Results: It was observed in the group of obese women with PCOS that 29 (72.5%) had
menstrual cycle variable and 27 (67.5%) had difficulty getting pregnant. According to waist-hip
ratio, higher average was also observed in obese PCOS (0.87). Blood level of HDL (36.9 mg/dL) and
ALT (29.3 U/L) were above normal levels in obese women with PCOS, with statistically significant
relationship. In the analysis of total and specific IgE to D. pteronyssinus high results were also
prevalent in obese PCOS, with blood level (365,22 IU/mL) and (6.83 kU/L), respectively, also
statistically significant. Conclusions: Observed predominance of cases with high levels of total IgE
in the group of obese women with PCOS, 28 (70%) of the participants, whose mean blood
concentration of the group was 365.22 IU/mL. In the analysis of Specific IgE between the groups,
the allergen Dermatophagoides pteronyssinus showed greater dispersion and average the results of
sensitization in the group of obese PCOS, whose mean blood concentration was 6.83 kU/l.
Keywords: Obesity, Allergens and Polycystic Ovary Syndrome
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/19495 |
| Date | 06 June 2014 |
| Creators | Aquino, Sheylena Fernandes |
| Contributors | 10861203453, http://lattes.cnpq.br/0091662650633339, Sales, Val?ria Soraya de Farias, 25069144472, http://lattes.cnpq.br/8525532896559374, R?go, Am?lia Cinthia Meneses do, 78914450368, http://lattes.cnpq.br/3240686272929972, Freitas, Janaina Cristiana de Oliveira Crispim, Cavalcanti J?nior, Geraldo Barroso |
| Publisher | Universidade Federal do Rio Grande do Norte, PROGRAMA DE P?S-GRADUA??O EM CI?NCIAS FARMACEUTICAS, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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