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Previous issue date: 2016-02-22 / A angiog?nese e a linfangiog?nese s?o altera??es tamb?m decorrentes da inflama??o gengival provocada por microrganismos presentes no biofilme dental, bem como pela a migra??o de c?lulas de defesa e secre??o de mediadores inflamat?rios no local da agress?o. Este estudo teve por objetivo avaliar a angiog?nese e linfangiog?nese em 90 esp?cimes de bi?psias de tecido gengival clinicamente saud?vel, com gengivite e com periodontite cr?nicas. Os cortes histol?gicos foram avaliados pela colora??o de hematoxilina e eosina e pela t?cnica de imunoistoqu?mica atrav?s da imunomarca??o de CD34 e podoplanina, para avaliar, respectivamente, o ?ndice angiog?nico e linfangiog?nico, por meio da t?cnica de contagem microvascular. Os resultados mostraram que h? correla??o entre os ?ndices (p=0,030), por?m, mostrou que na periodontite h? menos n?meros de vasos linf?ticos do que no tecido gengival clinicamente saud?vel (p=0,016). A podoplanina mostrou marca??o no epit?lio e que h? rela??o da intensidade de marca??o com a intensidade do infiltrado inflamat?rio, sendo mais intensa a marca??o na presen?a de infiltrado inflamat?rio severo (p=0,033). Concluiu-se neste estudo que h? menor n?mero de vasos sangu?neos na periodontite em compara??o com a gengiva clinicamente saud?vel. As sinaliza??es presentes no processo inflamat?rio, bem como o real papel da vasculatura sangu?nea e linf?tica gengival ainda n?o est?o totalmente elucidadas / Angiogenesis and lymphangiogenesis are changes that occur due to gingival
inflammation caused by microorganisms present in the biofilm, as well as the
migration of immune cells and secretion of mediators in the aggressed site. This
study aimed to research angiogenesis and lymphangiogenesis in 90 specimens of
clinically healthy, with gingivitis and chronic periodontitis gingival tissue biopsies. The
histological sections were evaluated by hematoxylin and eosin and the
immunohistochemical technique through immunostaining for CD34 and podoplanin.
To evaluate the angiogenic and lymphangiogenic indexes we performed a
microvessel counting technique. The results showed that there is a correlation
between the indexes (p = 0.030), however, we observed that periodontitis showed
less lymphatic vessels than clinically healthy gingival tissue (p = 0.016). Podoplanin
showed positive staining in the basal layers of the epithelium, and we observed a
relationship between immunostaining intensity and the intensity of inflammatory
infiltrate, with more intense staining in the presence of severe inflammatory infiltrate
(p = 0.033). For this study, we concluded that there are fewer blood vessels in
periodontitis compared with clinically healthy gingiva. The signaling present in the
inflammatory process and the actual role of gingival blood and lymphatic vasculature
are not fully understood, with further studies on angiogenesis and lymphangiogenesis
being suggested.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/20960 |
| Date | 22 February 2016 |
| Creators | Gon?alves, Patr?cia Guerra Peixe |
| Contributors | 02569549410, http://lattes.cnpq.br/4649601602612601, Santos, Bruna Rafaela Martins dos, 01163265497, http://lattes.cnpq.br/2611005967205110, Freitas, Roseana de Almeida, 28444361453, http://lattes.cnpq.br/9512014003639405, Gurgel, Bruno Cesar de Vasconcelos |
| Publisher | Universidade Federal do Rio Grande do Norte, PROGRAMA DE P?S-GRADUA??O EM PATOLOGIA ORAL, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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