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Previous issue date: 2010-06-28 / The aim of this study was to assess the acute and chronic effects of zinc
in serum iron profile of children aged 6-9 years in relation to nutritional status
and dietary intake.
The study participants were 11 children regardless of sex, aged 6-9
years. They were selected from three public schools of the city of Natal, Brazil.
Body mass index was used to assess nutritional status. In order to determine
the patterns of childhood growth and ideal weight we used the standards of the
World Health Organization. The dietary intake assessment was based on
information from a three-day prospective food survey. The variables were
energy intake, protein, lipids, carbohydrates, fiber, calcium, iron and zinc. All
children underwent an intravenous administration of zinc (IVAZn) before and
after oral administration of zinc (OAZn) (5 mg Zn / day) for three months. We
measured serum iron, hematocrit, hemoglobin and total protein, before and
after the use of oral zinc. The analysis of hematocrit, hemoglobin and total
protein was performed using standard methods of clinical laboratory. Zinc levels
and serum iron were measured by atomic absorption spectrophotometry. The
project was evaluated and approved by the Ethics in Research Committee of
Federal University of Rio Grande do Norte.
Results: All children had normal weight. The consumption of energy, fat, fiber,
calcium and iron were below recommended levels. However, the levels of
protein and carbohydrates were high. Protein and zinc increased significantly
after OAZn. Carbohydrate and protein were elevated in the blood. After OAZn,
both protein and zinc increased, being statistically significant.
Conclusion: The potential inhibitory effect of physiological or pharmacological
doses of zinc on the profile of serum iron was observed in children with healthy
weight and aged between 6 and 9 years. This negative effect of zinc did not
affect the levels of hematocrit or hemoglobin, and therefore did not cause
anemia. This was a multidisciplinary study, involving researchers from
medicine, nutrition and pharmacy. This met the requirements of
multidisciplinarity of the Post Graduate Program in Health Sciences of Federal
University of Rio Grande do Norte. / O objetivo do presente estudo foi avaliar os efeitos agudos e
cr?nicos de zinco no perfil de ferro s?rico de crian?as de 6 a 9 anos
relacionando com o estado nutricional e a ingest?o alimentar.
Os participantes deste estudo foram 11 crian?as independente do
sexo, com idade de 6 a 9 anos. Elas foram selecionadas de tr?s escolas
municipais da Cidade de Natal, Brasil. ?ndice de massa corporal foi utilizado
para avaliar o estado nutricional. Para determinar os padr?es de crescimento
infantil e para o peso ideal utilizaram-se os padr?es da Organiza??o Mundial da
Sa?de. A avalia??o do consumo alimentar baseou-se nas informa??es do
inqu?rito alimentar prospectivo de tr?s dias. As vari?veis estudadas foram a
ingest?o de energia, prote?na, lip?dios, carboidratos, fibras, c?lcio, ferro e zinco.
Todas as crian?as foram submetidas a uma administra??o venosa de zinco
(AVZn), antes e ap?s a administra??o oral de zinco (AOZn) (5 mg Zn/dia) por
tr?s meses. Dosaram-se ferro s?rico, hemat?crito, hemoglobina, prote?na total,
antes e ap?s o uso do zinco oral. A an?lise do hemat?crito, hemoglobina e
prote?nas totais foi realizada utilizando-se m?todos padronizados de laborat?rio
cl?nico. Os n?veis de zinco e de ferro s?rico foram medidos por
espectrofotometria de absor??o at?mica. O projeto foi avaliado e autorizado
pelo Comit? de ?tica em Pesquisa da Universidade Federal do Rio Grande do
Norte.
Resultados: Todas as crian?as tiveram peso normal. O consumo de energia,
de gorduras, de fibras, de c?lcio e de ferro estava abaixo dos n?veis
recomendados. No entanto, os percentuais de prote?na e carboidratos eram
elevados. Prote?na e zinco aumentaram significativamente ap?s a AOZn.
Prote?na e carboidrato estavam elevados no sangue. Ap?s a AOZn, tanto a
prote?na quanto o zinco aumentaram, em propor??es estatisticamente
significativas.
Conclus?o: O potencial efeito inibit?rio de dose fisiol?gica ou farmacol?gica de
zinco sobre o perfil s?rico do ferro foi observado em crian?as com peso
x
13
saud?vel e idade entre 6 e 9 anos. Esse efeito negativo do zinco n?o afetou os
n?veis de hemat?crito ou hemoglobina e, consequentemente, n?o causou
anemia. A realiza??o deste estudo teve car?ter multidisciplinar e envolveu
pesquisadores das ?reas de medicina, nutri??o e farm?cia. Neste aspecto,
preencheu os requisitos da multidisciplinaridade do Programa de P?sgradua??o
em Ci?ncias da Sa?de da Universidade Federal do Rio Grande do
Norte
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/13202 |
| Date | 28 June 2010 |
| Creators | Antunes, Maria de F?tima Rebou?as |
| Contributors | CPF:07658281115, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4783031A0, Ramos, Ana Maria de Oliveira, CPF:04045599487, http://lattes.cnpq.br/2365612055067945, Maranh?o, T?cia Maria de Oliveira, CPF:13049127449, http://lattes.cnpq.br/7869140767244263, D?rea, Jos? Garrofe, CPF:77043545820, http://lattes.cnpq.br/8972789547941543, Costa, Teresa Helena Macedo da, CPF:27938514187, http://lattes.cnpq.br/0273238836877709, Brand?o Neto, Jos? |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Ci?ncias da Sa?de, UFRN, BR, Ci?ncias da Sa?de |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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