Kinesin family member C1 (KIFC1) is a minus-end-directed motor protein that is critically
involved in microtubule crosslinking and spindle formation. KIFC1 is essential for supernumerary
centrosomes, and it is associated with the initiation and progression of cancers. In the present
study, we initially reviewed the The Cancer Genome Atlas database and observed that KIFC1 is
abundantly expressed in most types of tumors. We then analyzed the gene alteration profiles, protein
expressions, prognoses, and immune reactivities of KIFC1 in more than 10,000 samples from several
well-established databases. In addition, we conducted a gene set enrichment analysis to investigate
the potential mechanisms for the roles of KIFC1 in carcinogenesis. The pan-cancer analysis of KIFC1
demonstrates significant statistical correlations of the KIFC1 expression with the clinical prognoses,
the oncogenic signature gene sets, the myeloid-derived suppressor cell infiltration, the ImmunoScore,
the immune checkpoints, the microsatellite instabilities, and the tumor mutational burdens across
multiple tumors. These data may provide important information on the understanding of the role and
mechanisms of KIFC1 in carcinogenesis and immunotherapy, as well as on the clinical progression of
a variety of cancers.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:85993 |
| Date | 13 June 2023 |
| Creators | Wu, Hao, Duan, Yingjuan, Gong, Siming, Zhu, Qiang, Liu, Xuanyou, Liu, Zhenguo |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 637 |
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