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license.txt: 581 bytes, checksum: 44ea52f0b7567232681c6e3d72285adc (MD5) / Objectives: The present study aimed to verify if the salivary Endothelin-1 (ET-1) expression might represent an efficient biomarker to evaluate risk and prognosis from oral squamous cell carcinoma (OSCC).Methods: For the present study, saliva obtained from 20 healthy patients, 15 patients with oral leukoplakia (histopathologic diagnosis of hyperceratosis or severe dysplasia), 14 patients that had OSCC and were free of disease for more than 5 years, and from 20 patients with OSCC were collected. The ET-1 levels were quantified by means of ELISA. Results: No statistical differences were observed in the salivary ET-1 levels among the studied groups, even when patients with age superior to 65 years or with arterial hypertension were removed from the sample analysis. Likewise, when the sample was divided by sex, no statistical significance was observed among the four groups included in the study. Conclusions: Taking into account the present results, salivary ET-1 expression was not found to represent an efficient biomarker of either OSCC or oral leukoplakia. / Objetivos: Verificar se a Endotelina-1 (ET-1) salivar pode representar um biomarcador eficiente para avaliação de risco e prognóstico do carcinoma espinocelular bucal. Metodologia: Neste estudo, foi realizada coleta de saliva de 20 pacientes saudáveis, 15 pacientes portadores de leucoplasia oral (diagnóstico histopatológico de hiperceratose a displasia severa), 14 pacientes que já tiveram carcinoma espinocelular bucal (CEB) e estavam em um período pós-tratamento e livres de doença por, no mínimo cinco anos e, 20 pacientes portadores de CEB. A ET-1 foi quantificada na saliva através do método ELISA. Resultados: Não houve diferença estatisticamente significativa na expressão de ET-1 entre os grupos estudados, mesmo quando pacientes com idade superior a 65 anos ou hipertensos foram excluídos da análise. Da mesma forma, quando a amostra foi separada por sexo, também não houve diferença significativa. Conclusões: A ET-1 salivar não se mostrou um biomarcador eficiente do carcinoma espinocelular bucal.
| Identifer | oai:union.ndltd.org:IBICT/urn:repox.ist.utl.pt:RI_PUC_RS:oai:meriva.pucrs.br:10923/447 |
| Date | January 2010 |
| Creators | Hoffmann, Renata da Rocha |
| Contributors | Campos, Maria Martha |
| Publisher | Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Source | reponame:Repositório Institucional da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
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