Abstract
OBJECTIVES:
The objective of the present study is to compare the effect of systemic adjunctive use of azithromycin with amoxicillin/metronidazole to scaling and root planing (SRP) in a clinical study.
MATERIALS AND METHODS:
Data from 60 individuals with chronic periodontitis were evaluated after full-mouth SRP. Antibiotics were given from the first day of SRP, in the test group (n = 29), azithromycin for 3 days and, in the control group (n = 31), amoxicillin/metronidazole for7 days. Probing depth (PD), attachment level (AL), and bleeding on probing (BOP) were recorded at baseline and after 3 and 12 months. Gingival crevicular fluid was analyzed for matrix metalloprotease (MMP)-8 and interleukin (IL)-1beta levels. Subgingival plaque was taken for assessment of the major bacteria associated with periodontitis.
RESULTS:
In both groups, PD, AL, and BOP were significantly reduced (p < 0.001). A few significant differences between the groups were found; AL and BOP were significantly better in the test than in the control group at the end of the study (p = 0.020 and 0.009). Periodontopathogens were reduced most in the test group.
CONCLUSIONS:
A noninferiority of the treatment with azithromycin in comparison with amoxicillin/metronidazole can be stated. The administration of azithromycin could be an alternative to the use of amoxicillin/metronidazole adjunctive to SRP in patients with moderate or severe chronic periodontitis; however, a randomized placebo-controlled multicenter study is needed.
CLINICAL RELEVANCE:
Application of azithromycin as a single antibiotic for 3 days might be considered as an additional adjunctive antibiotic to SRP in selected patients.:Inhaltsverzeichnis
1 Einleitung 7
1.1 Klassifikation der Parodontitiden 7
1.2 Prävalenz der Parodontitis 8
1.3 Parodontales Erregerspektrum 9
2 Aufgabenstellung 12
3 Material und Methode 13
3.1 Erhobene Variablen 15
3.2 Therapie und Nachbehandlung 20
3.3 Biochemische und mikrobiologische Analyse 21
3.3.1 Probenentnahme 21
3.3.2 Analyse 22
3.4 Statistische Auswertung 23
4 Ergebnisse 25
5 Diskussion 33
6 Zusammenfassung 40
7 Literaturverzeichnis 44
8 Anhang 61
9 Publikation 65
10 Lebenslauf 66
11 Danksagung 67
12 Erklärung über die eigenständige Abfassung der Arbeit 68
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:15519 |
| Date | 01 March 2017 |
| Creators | Buchmann, Andreas |
| Contributors | Jentsch, Holger, Jakstat, Holger A., Sigusch, Bernd W., Universität Leipzig |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | German |
| Detected Language | English |
| Type | doc-type:doctoralThesis, info:eu-repo/semantics/doctoralThesis, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
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