Psoriasis is a chronic inflammatory disease of the skin and joints. More recent data
emphasize an association with dysregulated glucose and fatty acid metabolism, obesity,
elevated blood pressure and cardiac disease, summarized as metabolic syndrome.
TNF-a and IL-17, central players in the pathogenesis of psoriasis, are known to
impair bone formation. Therefore, the relation between psoriasis and bone metabolism
parameters was investigated. Two serum markers of either bone formation—N-terminal
propeptide of type I procollagen (P1NP) or bone resorption—C-terminal telopeptide
of type I collagen (CTX-I)—were analyzed in a cohort of patients with psoriasis
vulgaris. In patients with psoriasis, P1NP serum levels were reduced compared to
gender-, age-, and body mass index-matched healthy controls. CTX-I levels were
indistinguishable between patients with psoriasis and controls. Consistently, induction
of psoriasis-like skin inflammation in mice decreases bone volume and activity of
osteoblasts. Moreover, efficient anti-psoriatic treatment improved psoriasis severity, but
did not reverse decreased P1NP level suggesting that independent of efficient skin
treatment psoriasis did affect bone metabolism and might favor the development of
osteoporosis. Taken together, evidence is provided that bone metabolism might be
affected by psoriatic inflammation, which may have consequences for future patient
counseling and disease monitoring.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:84321 |
| Date | 27 March 2023 |
| Creators | Mentzel, Julia, Kynast, Tabea, Kohlmann, Johannes, Kirsten, Holger, Blüher, Matthias, Simon, Jan C., Kunz, Manfred, Saalbach, Anja |
| Publisher | Frontiers Research Foundation |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2296-858X, 730164 |
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