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Previous issue date: 2017-11-17 / A pediculose ? caracterizada pela infesta??o por Pediculus humanus capitis no homem. Desde o ano de 1963 a pediculose vem crescendo significativamente, principalmente, no ambiente escolar e nos centros urbanos. Isso decorre da aglomera??o de pessoas, tendo em vista a facilidade com que ? transmitida. Os procedimentos terap?uticos atuais apresentam efeitos colaterais, oferecendo risco ? sa?de do hospedeiro e contribuindo para a resist?ncia do parasita aos f?rmacos utilizados, elevando os custos com o tratamento. Os autores se propuseram a desenvolver um produto alternativo at?xico, biocompat?vel, biodegrad?vel e que desfavore?a a muta??o gen?tica apresentada pelos piolhos aos tratamentos dispon?veis atualmente, tudo isso suportado na gest?o da inova??o. Para gerir o projeto foram preparadas amostras do hidrogel ? dispers?o de quitosana em solu??o aquosa de ?cido ac?tico com dissolu??o pr?via do metilparabeno e adi??o de ess?ncia e glicerina - para posterior uso no ensaio in vitro e caracteriza??o f?sico-qu?mica do produto. A caracteriza??o f?sico-qu?mica das amostras foi realizada atrav?s de an?lise organol?ptica, da an?lise reol?gica e aferi??o do pH. A valida??o metodol?gica do produto foi realizada atrav?s do ensaio in vitro, que envolveu a sele??o das amostras, a coleta e padroniza??o de mechas de cabelo, exame e classifica??o da pediculose e, por fim, a aplica??o e constata??o da efici?ncia do produto. A gest?o de custo foi realizada a partir dos c?lculos de custos fixos e vari?veis, necess?rios ? produ??o do hidrogel. Foi realizado o dep?sito do pedido de patente junto ao Instituto Nacional da Propriedade Industrial (INPI) sob o registro n? BR 1020150251793 para garantir o direito ? propriedade intelectual sobre o produto. Os resultados obtidos durante a caracteriza??o f?sico-qu?mica do hidrogel revelaram estabilidade na colora??o e no odor durante os 60 dias em que o hidrogel foi armazenado. Observou-se no estudo reol?gico o comportamento caracter?stico de fluidos pseudopl?sticos das dispers?es de quitosana preparadas, dada ? redu??o observada na viscosidade em fun??o da eleva??o da taxa de cisalhamento. O percentual de remo??o dos ovos na amostra tratada com o hidrogel foi maior (83% dos ovos na primeira aplica??o) do que o observado na exclusiva aplica??o de solu??o de ?cido ac?tico (32%). O tratamento utilizando o produto proposto, denominado hidrogel, pode ser disponibilizado a um pre?o competitivo, tendo em vista a m?dia de pre?os praticados pelos concorrentes. / Pediculosis is characterized by infestation by Pediculus humanus capitis in humans. Since 1963 pediculosis has been growing significantly, mainly in the school environment and in urban centers. This is due to the agglomeration of people, given the ease with which it is transmitted. The current therapeutic procedures present side effects, offering a risk to the health of the host and contributing to the resistance of the parasite to the drugs used, increasing costs with the treatment. The authors set out to develop an alternative, non-toxic, biocompatible, biodegradable product that would undermine the genetic mutation presented by lice to currently available treatments, all supported in the management of innovation. To manage the project, samples of the hydrogel - chitosan dispersion in aqueous solution of acetic acid were prepared with previous dissolution of methylparaben and addition of essence and glycerine - for later use in the in vitro test and physicochemical characterization of the product. The physico-chemical characterization of the samples was performed through organoleptic analysis, rheological analysis and pH measurement. The methodological validation of the product was performed through the in vitro test, which involved sample selection, collection and standardization of hair strands, examination and classification of pediculosis and, finally, application and verification of product efficiency. The cost management was carried out from the calculations of fixed and variable costs, necessary for the production of the hydrogel. The filing of the patent application was filed with the National Institute of Industrial Property (INPI) under registry number BR 1020150251793 to guarantee the right to intellectual property on the product. The results obtained during the physico-chemical characterization of the hydrogel revealed staining and odor stability during the 60 days in which the hydrogel was stored. It was observed in the rheological study the characteristic behavior of pseudoplastic fluids of the prepared chitosan dispersions, due to the observed reduction in viscosity as a function of the elevation of the shear rate. The percentage of egg removal in the hydrogel treated sample was higher (83% of the eggs in the first application) than that observed in the application of acetic acid solution (32%). The treatment using the proposed product, called hydrogel, can be made available at a competitive price, given the average prices of concurrents.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/24913 |
| Date | 17 November 2017 |
| Creators | Lima, Lucimar Fernandes de |
| Contributors | 79102310406, Brand?o, Glaucio Bezerra, 59184574453, Azevedo, Eduardo Pereira de, 03207095402, Pinheiro, Francisco Irochima |
| Publisher | PROGRAMA DE P?S-GRADUA??O EM CI?NCIA, TECNOLOGIA E INOVA??O, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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