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Previous issue date: 2011-02-28 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPq / This study aimed to evaluate the prevalence of antibodies against Neorickettsia risticii in
horses in the microregion of Itagua? RJ, show possible associated factors and identify the
agent by molecular techniques. The study was conducted in the districts of Serop?dica, Itagua?
and Mangaratiba, Rio de Janeiro. The 350 blood samples were obtained by convenience from
horse properties belonging to the region. Serologic testing was performed by
Immunofluorescence Assay (IFAI) for N. risticii, being considered positive samples titer
1:50. To evaluate risk factors associated with the presence of antibodies to N. risticii an
epidemiological questionnaire was applied to the owners or guardians of animals, which
aimed especially farm characteristics and management of animals. Hematological and clinical
evaluation was performed for all animals. Molecular analysis by a Real Time PCR was
performed from leukocyte cover. The prevalence of antibodies anti-N.risticii in horses of the
region of Itagua? was 26.3% (92/350). The frequencies of IgG anti-N.rristicii were 52.2%
(48/92) for titers of 1:50, zero for titers of 1:100, 13% (12/92) for titles of 1:200, 28.3%
(26/92) for evidence of 1:400 and 6.5% (6 / 92) for titles of 1:800. The age and quality level
of the properties were associated (p <0.05) with horses seropositivity for N. risticii. DNA
from N. risticii was not detectable in samples of this study. Also no significant changes in the
clinical evaluation of animals was found in relation to seropositivity for the agent. Despite
showing association (p <0.05) between the seropositivity of the animals and changes in white
blood cell of negative animals, these changes were not outside reference limits for the species
evaluated. The existence of horses seropositive for N. risticii indicates the presence of this
agent in the microregion of Itagua?. / O presente estudo teve por objetivo avaliar a preval?ncia de anticorpos contra Neorickettsia
risticii em equinos na microrregi?o de Itagua?-RJ, demonstrar os poss?veis fatores associados
e identificar o agente atrav?s de t?cnicas moleculares. O estudo foi conduzido nos munic?pios
de Serop?dica, Itagua? e Mangaratiba, estado do Rio de Janeiro. As 350 amostras de sangue
foram obtidas por conveni?ncia, das propriedades de cria??o de equinos pertencentes ? regi?o.
O teste sorol?gico foi realizado atrav?s da Rea??o de Imunofluoresc?ncia Indireta (RIFI) para
N. risticii, sendo consideradas positivas amostras com t?tulo 1:50. Para avalia??o dos fatores
de risco associados ? presen?a de anticorpos de N. risticii, aplicou-se um question?rio
epidemiol?gico com os propriet?rios e/ou respons?veis dos animais, destacando
caracter?sticas da propriedade e manejo dos animais. Realizou-se hemograma e avalia??o
cl?nica de todos os animais. As an?lises moleculares atrav?s da t?cnica de Real Time PCR
foram realizadas a partir de capa leucocit?ria. A preval?ncia de anticorpos anti-N. risticii em
equinos da microrregi?o de Itagua? foi de 26,3% (92/350) pela RIFI. As frequ?ncias de
anticorpos IgG anti-N. risticii foram 52,2% (48/92) para titula??es de 1:50, zero para
titula??es de 1:100, 13% (12/92) para t?tulos de 1:200, 28,3% (26/92) para t?tulos de 1:400 e
6,5% (6/92) para t?tulos de 1:800. A idade e o n?vel de qualidade das propriedades
apresentaram associa??o (p<0,05) com a soropositividade dos equinos para N. risticii. N?o foi
detectado o DNA de N. risticii nas amostras do presente estudo. Tamb?m n?o foram
evidenciadas altera??es significativas na avalia??o clinica dos animais, em rela??o ?
soropositividade para o agente. Apesar de haver associa??o (p<0,05) entre a soropositividade
dos animais e altera??es no leucograma dos animais negativos, estas altera??es n?o estiveram
fora dos limites de refer?ncia para a esp?cie animal avaliada. A exist?ncia de equinos
soropositivos para N. risticii indica a circula??o desse agente na microrregi?o de Itagua?
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/1223 |
| Date | 28 February 2011 |
| Creators | Roier, Erica Cristina Rocha |
| Contributors | Massard, Carlos Luiz, Baldani, Cristiane Divan, Leite, Rom?rio Cerqueira, Linhares, Guido Fontgalland Coelho, Barreira, Jairo Dias, Grisi, Laerte |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Ci?ncias Veterin?rias, UFRRJ, Brasil, Instituto de Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
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