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Previous issue date: 2011-04-26 / This study was performed at Hospital de Cl?nicas Veterin?rias do Centro Universit?rio
Pl?nio Leite Itabora?, Rio de Janeiro (Veterinary Hospital of Pl?nio Leite University, Itabora?,
Rio de Janeiro) to monitor the hepatic biochemical profile of cats and their clinical parameters
when submitted to continuous infusion of propofol at a 0,3 mg/kg/min dosage, for 90 minutes,
and comparing to results obtained from cats who received continuous infusion of saline
solution. Both groups were analyzed during a pre-determined period of time totalizing 28
days of observation and analysis. The following enzymes activity levels were determined:
Aminotransferase (AST), Alanina-Aminotransferase (ALT), Gamma Glutamyl
Transpeptidase (GGT) and Alkaline Fosfatasis (FA); serum levels of Albumin (A), Total
Bilirrubin (BT) and Total Serum Proteins (PT), yet registering Respiratory (FR) and Heart
Rate (FC), Systolic Blood Pressure (PAS), Mean Arterial Blood Pressure (PAM), Diastolic
Blood Pressure (PAD) and Oxygen Partial Saturation (SPO2). Twenty healthy cats were
analyzed on this study, their weights varying from two to four kilos and ages between three to
five years old, submitted to experimental procedures performed during the months of January
and February, 2010. The analysis of these results showed a major difference (p<0,05) between
the ALT serum activities at the following positions: T2 (30 minutes), T3 (60 minutes), T5 (12
hours) and T9 (28 days); AST serum activities at T2, FA serum activities at T2, T6 (seven
days) and T8 (21 days), emphasizing the fact only at this last position the GP levels were
greater than GC; in the heart rate at T1 position (the beginning of this experiment), without
compromising animals physical condition. None of the animals presented averages above
parameters of normality. The other parameters examined did not present any significant
differences, concluding that total intravenous anesthesia using continuous infusion of
propofol was safe to contain cats in invasive surgical procedures, therefore providing more
information regarding the safe use of this drug in animals. / O trabalho foi desenvolvido no Hospital de Cl?nicas Veterin?rias do Centro
Universit?rio Pl?nio Leite, em Itabora?, RJ, com o intuito de monitorar perfil bioqu?mico
hep?tico e par?metros cl?nicos de gatos submetidos ? infus?o cont?nua de propofol (GP) na
dose de 0,3 mg/kg/min, durante 90 minutos, e comparando-se com resultados observados em
gatos do grupo controle (GC), que receberam infus?o cont?nua de solu??o fisiol?gica. Os dois
grupos foram avaliados em espa?os de tempo pr?-determinados, totalizando 28 dias de
observa??es e an?lises. Foram determinadas as atividades s?ricas de aspartatoaminotransferase
(AST), alanina-aminotransferase (ALT), gama-glutamil transpeptidase
(GGT) e fosfatase alcalina (FA), determinadas as concentra??es s?ricas de Albumina (A),
Bilirrubina total (BT) e Prote?nas Totais s?ricas (PT), registrando-se ainda as Frequ?ncias
Respirat?rias (FR) e Card?acas (FC), Temperatura Retal (T), Press?es Arteriais Sist?licas
(PAS), M?dias (PAM) e Diast?licas (PAD) e Satura??o parcial de O2 (SPO2). Foram
utilizados no estudo 20 gatos h?gidos, com pesos variando entre dois e quatro kg e idades
entre tr?s e cinco anos, que foram submetidos aos procedimentos experimentais no per?odo
compreendido entre janeiro e fevereiro de 2010. A an?lise dos resultados demostraram que
houve diferen?a significativa (p<0,05) nas atividades s?ricas de ALT nos momentos T2 (30
minutos), T3 (60 minutos), T5 (12 horas) e T9 (28 dias); nas atividades s?ricas de AST no
momento T2; nas atividades s?ricas de FA nos momentos T2, T6 (7 dias) e T8 (21 dias),
sendo que, somente neste ultimo momento as dosagens do GP foram maiores que no GC; na
frequ?ncia card?aca no momento T1 (in?cio do experimento), sem causar qualquer
comprometimento ? sa?de dos animais. Nenhum dos animais apresentou m?dias acima dos
par?metros de normalidade. Os outros par?metros analisados n?o tiveram diferen?as
significativas, concluindo-se que a anestesia intravenosa total com uso de propofol em infus?o
cont?nua foi segura para conten??o de gatos em procedimentos incruentos, contribuindo assim
para maiores informa??es em rela??o ao uso desse f?rmaco nesses animais
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/1188 |
| Date | 26 April 2011 |
| Creators | Ferreira, Janh Carlo de Amorim |
| Contributors | Botelho, Gilberto Garcia |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Ci?ncias Veterin?rias, UFRRJ, Brasil, Instituto de Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
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