Thesis (MTech (Biomedical Technology))--Cape Peninsula University of Technology, 2006 / Research has shown that the activation of the NO-cGMP pathway leads to
myocardial protection from oxidative stress conditions, such as ischaemia and
reperfusion. Few of these studies have however combined diet induced oxidative
stress with ischaemia/reperfusion injury. Although little is known about the effects
of supplements such as red palm oil (RPO) on the NO-cGMP pathway, research
has shown that dietary RPO-supplementation improved reperfusion aortic output
recovery through mechanisms that may include activation of the NO-cGMP- and
inhibition of the cAMP pathway. RPO is an antioxidant-rich oil containing ~carotene
and Vitamin E (tocopherols and tocotrienols). The aims of this study
were to determine: 1) whether RPO-supplementation of an oxidative risk induced
diet (ORD) and a high saturated fat diet (HFD) offers protection against
ischaemia/reperfusion injury in the isolated perfused rat heart and 2) the possible
mechanisms for this protection.
Male Wistar rats were randomly divided into four groups for a period of 14 weeks
according to the dietary supplementation they received. The control groups
received either an oxidative risk induced diet (ORD) or a high saturated fat diet
(HFD), while the experimental groups received an ORD supplemented with RPO
(ORD+RPO) or a HFD supplemented with RPO (HFD+RPO).
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:cput/oai:localhost:20.500.11838/1470 |
| Date | January 2006 |
| Creators | Bester, Dirk Jacobus |
| Publisher | Cape Peninsula University of Technology |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Rights | http://creativecommons.org/licenses/by-nc-sa/3.0/za/ |
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