Yes / Preliminary evidence suggests that goal-oriented cognitive rehabilitation (CR) may be a clinically
effective intervention for people with early-stage Alzheimer's disease, vascular or mixed dementia and their carers.
This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with
early-stage dementia and their carers.
Methods/design: In this multi-centre, single-blind randomised controlled trial, 480 people with early-stage
dementia, each with a carer, will be randomised to receive either treatment as usual or cognitive rehabilitation
(10 therapy sessions over 3 months, followed by 4 maintenance sessions over 6 months). We will compare the
effectiveness of cognitive rehabilitation with that of treatment as usual with regard to improving self-reported and
carer-rated goal performance in areas identified as causing concern by people with early-stage dementia;
improving quality of life, self-efficacy, mood and cognition of people with early-stage dementia; and reducing stress
levels and ameliorating quality of life for carers of participants with early-stage dementia. The incremental
cost-effectiveness of goal-oriented cognitive rehabilitation compared to treatment as usual will also be examined.
Discussion: If the study confirms the benefits and cost-effectiveness of cognitive rehabilitation, it will be important
to examine how the goal-oriented cognitive rehabilitation approach can most effectively be integrated into routine
health-care provision. Our aim is to provide training and develop materials to support the implementation of this
approach following trial completion.
Trial registration: Current Controlled Trials ISRCTN21027481
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/5615 |
| Date | 27 May 2013 |
| Creators | Clare, L., Bayer, A., Burns, A., Corbett, A., Jones, R., Knapp, M., Kopelman, M.D., Kudlicka, A., Leroi, I., Oyebode, Jan, Pool, J., Woods, B., Whitaker, R. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Published version |
| Rights | (c) 2013 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/deed.en), © 2013 Clare, L. et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://www.creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., CC-BY |
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