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Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers.

The laminin-binding integrin (LBI) family are cell adhesion molecules that are essential for invasion and metastasis of human epithelial cancers and cell adhesion mediated drug resistance. We investigated whether copy number alteration (CNA) or mutations of a five-gene signature (ITGB4, ITGA3, LAMB3, PLEC, and SYNE3), representing essential genes for LBI adhesion, would correlate with patient outcomes within human epithelial-type tumor data sets currently available in an open access format.

Identiferoai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/615112
Date January 2016
CreatorsHarryman, William L, Pond, Erika, Singh, Parminder, Little, Andrew S, Eschbacher, Jennifer M, Nagle, Raymond B, Cress, Anne E
ContributorsUniv Arizona, Ctr Canc
PublisherE-CENTURY PUBLISHING CORP
Source SetsUniversity of Arizona
LanguageEnglish
Detected LanguageEnglish
TypeArticle
RightsCreative Commons Attribution Non-Commercial License
Relationhttp://www.ajtr.org/files/ajtr0019463.pdf

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