Yes / A set of water-swollen core−shell particles was
synthesized by emulsion polymerization of a 1,3-dioxolane
functional monomer in water. After removal of the 1,3-
dioxolane group, the particles’ shells were shown to swell in
aqueous media. Upon hydrolysis, the particles increased in size
from around 70 to 100−130 nm. A bicinchoninic acid assay
and ζ-potential measurements were used to investigate the
adsorption of lysozyme, albumin, or fibrinogen. Each of the
core−shell particles adsorbed significantly less protein than the
noncoated core (polystyrene) particles. Differences were
observed as both the amount of difunctional, cross-linking
monomer and the amount of shell monomer in the feed were changed. The core−shell particles were shown to be resistant to
protein adsorption, and the degree to which the three proteins adsorbed was dependent on the formulation of the shell. / EPSRC and MRC
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/11485 |
| Date | 13 February 2017 |
| Creators | Mckenzie, A., Hoskins, Richard, Swift, Thomas, Grant, Colin A., Rimmer, Stephen |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Published version |
| Rights | (c) 2017 ACS. This is an Open Access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html), which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
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