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Previous issue date: 2010-06-19 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico / Several pharmaceutical products have been developed in recent years aiming to
enhance the treatment of diseases by increasing the effectiveness of drugs. Many
of these new products are based on new drug delivery systems. Among these,
microemulsions, which were first studied in 1943 by Hoar and Schulman, is of
great interest. Microemulsion can be defined as a thermodynamically stable,
isotropic, translucent and transparent system of two immiscible liquids stabilized
by a surfactant film located in the oil / water interface. The aim os this work was
the incorporation of Amphotericin B and Simvasatin to a microemulsion system
and analyzes its physicochemical properties and their therapeutical activity when
incorporated into this system. Some very promising results were achieved as the
reduction of the toxicity and maintenance of the efficacy of the Amphotericin B
incorpored into a microemulsion, which was demonstrated in the in vitro
pharmacotoxicological study. As for the incorporation of Simvastatin in
microemulsion, it was observed a significant improvement in the potential antiinflammatory
and anti-infective properties when the system was use to treat
infected wounds (simvastatin pleiotropic effects). Therefore, it can be concluded
that the incorporation of these drugs into microemulsion system reveal the
potential of microemulsions as a promising and novel dosage form, qualifying
them for future trials in order to make them available in the pharmaceutical market / In?meros produtos farmac?uticos v?m sendo desenvolvidos nos
?ltimos anos com a finalidade de incrementar o tratamento de doen?as pelo
aumento da efic?cia de f?rmacos. Grande parte destes novos produtos est?
baseada nos novos sistemas transportadores de f?rmacos. Entre eles destacamse
as microemuls?es, que foram primeiramente estudadas em 1943 por Hoar e
Schulman. Microemuls?o pode ser definida como um sistema
termodinamicamente est?vel, isotr?pico, transl?cido e transparente de dois
l?quidos imisc?veis estabilizados por um filme de tensoativos localizados na
interface ?leo/?gua. O objetivo deste trabalho foi incorporar anfotericina B e
sinvastatina em um sistema microemulsionado e analisar suas propriedades
f?sico-qu?micas e suas a??es terap?uticas ap?s a incorpora??o destes f?rmacos
ao sistema. Alguns resultados muito promissores foram alcan?ados como a
redu??o da toxicidade e a perman?ncia da efic?cia da anfotericina B incorporada
em uma microemuls?o durante o estudo farmacotoxicol?gico in vitro. Quanto ?
incorpora??o da sinvastatina na microemuls?o, foi constatada uma melhora
significativa no potencial antiinflamat?rio e antiinfeccioso (efeitos pleiotr?picos da
sinvastatina) em feridas tratadas com esse sistema. Portanto, podemos concluir
que a incorpora??o desses f?rmacos em sistemas microemulsionados faz das
microemuls?es uma nova e promissora apresenta??o farmac?utica, habilitando-a
a futuros ensaios com a finalidade de torn?-los dispon?veis no mercado
farmac?utico
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/13194 |
| Date | 19 June 2010 |
| Creators | Damasceno, Bolivar Ponciano Goulart de Lima |
| Contributors | CPF:38878240400, http://lattes.cnpq.br/6907806915889763, Maranh?o, T?cia Maria de Oliveira, CPF:13049127449, http://lattes.cnpq.br/7869140767244263, Pedrosa, Matheus de Freitas Fernandes, CPF:96728647449, http://lattes.cnpq.br/2929963416385218, Frezard, Frederic Jean Georges, CPF:01176053604, http://lattes.cnpq.br/1339716092644256, Badar?, Roberto Jos? da Silva, CPF:07392940597, http://lattes.cnpq.br/2172673138599748, Egito, Eryvaldo S?crates Tabosa do |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Ci?ncias da Sa?de, UFRN, BR, Ci?ncias da Sa?de |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/embargoedAccess |
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