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"Espectroscopia de prótons na demência de Alzheimer e no comprometimento cognitivo" / Proton spectroscopy in Alzheimer's dementia and amnestic mild cognitive impairment

Estudamos os achados da espectroscopia de prótons no córtex parietal-cíngulo posterior e das escalas MEEM, BRDS e FAST em pacientes com doença de Alzheimer - DA, comprometimento cognitivo amnéstico - CCA e controles normais - CN. Apenas as razões NAA/Cr e MI/NAA diferenciaram (p < 0.002) os grupos DA e CN. Houve correlação significativa do NAA/Cr e do MI/NAA com o BRDS (pontuação total - PT; atividades cotidianas - AC) e FAST, e do MI/NAA com o MEEM. Houve acréscimo de 5% na especificidade (CN x DA; CN x CCA), e de 2.4% (CN x DA) e 3.4% (CN x CCA) na acurácia diagnóstica, ao adicionar as razões NAA/Cr e MI/NAA às escalas BRDS (PT e AC) e FAST, aumentando a detecção de indivíduos com CCA e DA / We studied the findings of proton spectroscopy of the posterior parietal-cingulate cortex, and of MMSE, BRDS and FAST scales in subjects with Alzheimer disease - AD, amnestic mild cognitive impairment - MCI-A and normal controls - NC. Only NAA/Cr and MI/NAA differentiated (p < 0.002) the AD and NC groups. Significant correlation was found between NAA/Cr and MI/NAA with BRDS (total score - TS; everyday activities - EA) and FAST scales, and between MI/NAA and MMSE. Specificity increased in 5% (NC x AD; NC x MCI-A) and diagnostic accuracy in 2.4% (NC x AD) and 3.4% (NC x MCI-A) when NAA/Cr and MI/NAA ratios were added up to BRDS (TS & EA) and FAST scales, increasing MCI-A and AD detectability

Identiferoai:union.ndltd.org:IBICT/oai:teses.usp.br:tde-12042006-090739
Date12 December 2005
CreatorsAndrea Silveira de Souza
ContributorsCassio Machado de Campos Bottino, Mario Rodrigues Louzã Neto, Ricardo Nitrini, Ivan Hideyo Okamoto, Rodrigo Rizek Schultz
PublisherUniversidade de São Paulo, Psiquiatria, USP, BR
Source SetsIBICT Brazilian ETDs
LanguagePortuguese
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis
Sourcereponame:Biblioteca Digital de Teses e Dissertações da USP, instname:Universidade de São Paulo, instacron:USP
Rightsinfo:eu-repo/semantics/openAccess

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