DCs play a pivotal role in orchestrating innate and adaptive antitumor immunity. Activated DCs can produce large amounts of various proinflammatory cytokines, initiate T-cell responses, and exhibit direct cytotoxicity against tumor cells. They also efficiently enhance the antitumoral properties of NK cells and T lymphocytes. Based on these capabilities, immunogenic DCs promote tumor elimination and are associated with improved survival of patients. Furthermore, they can essentially contribute to the clinical efficacy of immunotherapeutic strategies for cancer patients. However, depending on their intrinsic properties and the tumor microenvironment, DCs can be rendered dysfunctional and mediate tolerance by producing immunosuppressive cytokines and activating Treg cells. Such tolerogenic DCs can foster tumor progression and are linked to poor prognosis of patients. Here, we focus on recent studies exploring the phenotype, functional orientation, and clinical relevance of tumor-infiltrating conventional DC1, conventional DC2, plasmacytoid DCs, and monocyte-derived DCs in translational and clinical settings. In addition, recent findings demonstrating the influence of DCs on the efficacy of immunotherapeutic strategies are summarized.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:91352 |
| Date | 04 June 2024 |
| Creators | Plesca, Ioana, Müller, Luise, Böttcher, Jan P., Medyouf, Hind, Wehner, Rebekka, Schmitz, Marc |
| Publisher | Wiley-VCH |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1521-4141, 10.1002/eji.202149487, info:eu-repo/grantAgreement/Bavaria International Junior Research Group/Elite Network/N-LW-2016-370/, info:eu-repo/grantAgreement/Deutsche Forschungsgemeinschaft/Inverses kamerabasiertes Weitfeld-Fluoreszenzmikroskop/442405234/, info:eu-repo/grantAgreement/Deutsche Forschungsgemeinschaft/Konfokales Laser Scanning Mikroskop mit Spektraler Detektion und FLIM/424926990/, info:eu-repo/grantAgreement/Deutsche Forschungsgemeinschaft/Die Rolle von cDC1 Heterogenität für die Immunantwort gegen Krebs/449174900/, info:eu-repo/grantAgreement/Deutsche Forschungsgemeinschaft/SPP 2306: Ferroptose: Von der Grundlagenforschung zur klinischen Anwendung/461704785//Die Rolle des ferroptotischen Zelltods für die Regulation der anti-tumor Immunität durch dendritische Zellen |
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