Philosophiae Doctor - PhD / Breast cancer is regarded as the most common cancer in South Africa and its rate of
occurrence is increasing. About one in every 31 South African women are at the risk of
developing breast cancer and early diagnosis and treatment guarantee 90% survival rate.
Tamoxifen is the drugs of choice for the treatment of all stages of breast cancer. The drug
binds with estrogen receptor (ER) to minimize the transcription of estrogen dependent genes.
However, nearly 50% of ER-positive breast cancer patients either become resistant or fail to
respond to tamoxifen resulting in a serious clinical challenge in breast cancer management.
The Grand Health Challenges of South Africa includes the development of cost effective
diagnostic systems suitable for early detection of diseases and drug resistivity for timely
invention and better patient management. / 2020-08-31
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uwc/oai:etd.uwc.ac.za:11394/5505 |
| Date | January 2017 |
| Creators | Feleni, Usisipho |
| Contributors | Iwuoha, Emmanuel I. |
| Publisher | University of the Western Cape |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Rights | University of the Western Cape |
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