Lee, Siu Fung. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2011. / Includes bibliographical references (leaves 89-91). / Abstracts in English and Chinese. / Content --- p.i / Acknowledgments --- p.iv / Abstract --- p.V / Abbreviations and Acronyms --- p.vii / Publications Originated from the Work of this Thesis --- p.ix / Chapter Chapter 1- --- Introduction / Chapter 1.1 --- Nanoparticle-based drug delivery --- p.1 / Chapter 1.2 --- Magnetic nanoparticle --- p.5 / Chapter 1.3 --- Iron oxide nanoparticle --- p.6 / Chapter 1.3.1 --- Coprecipitation --- p.7 / Chapter 1.3.2 --- Hydrothermal reaction --- p.7 / Chapter 1.3.3 --- Sol-gel reaction --- p.8 / Chapter 1.3.4 --- Solvothermal reaction --- p.8 / Chapter 1.3.5 --- Architecture of iron oxide nanoparticles as drug carriers --- p.9 / Chapter 1.4 --- Supramolecular chemistry involved in controlled release drug delivery system --- p.10 / Chapter 1.5 --- Nano valve --- p.15 / Chapter 1.6 --- Aim of project --- p.17 / Chapter Chapter 2- --- Stimuli-Responsive Drug Delivery Nanosystems based on Fe3O4@SiO2@crown ether Nanoparticles / Chapter 2.1 --- Background --- p.19 / Chapter 2.2 --- Synthesis of the dibenzo-crown ethers --- p.21 / Chapter 2.3 --- Synthetic method of functionalized nanoparticles --- p.22 / Chapter 2.4 --- Characterization of dibenzo-crown ethers --- p.25 / Chapter 2.4.1 --- Nuclear magnetic resonance (NMR) spectroscopy --- p.25 / Chapter 2.4.2 --- Mass spectrometry (MS) --- p.27 / Chapter 2.4.3 --- Infrared (IR) spectroscopy --- p.28 / Chapter 2.5 --- Characterization of nanoparticles --- p.29 / Chapter 2.5.1 --- Transmission electron microscopy (TEM) --- p.29 / Chapter 2.5.2 --- Energy-dispersive X-ray (EDX) spectroscopy --- p.34 / Chapter 2.5.3 --- IR spectroscopy --- p.39 / Chapter 2.5.4 --- Thermogravimetric analysis (TGA) --- p.41 / Chapter 2.5.5 --- Nitrogen absorption/desorption isotherms --- p.44 / Chapter 2.6 --- Biological study of functionalized nanoparticles --- p.45 / Chapter 2.6.1 --- Cytotoxicity study --- p.45 / Chapter 2.6.2 --- Cell adhesion study --- p.46 / Chapter 2.6.3 --- Cell proliferation study --- p.47 / Chapter 2.6.4 --- Cellular uptake of nanoparticles --- p.50 / Chapter 2.7 --- Drug loading under different stimuli --- p.54 / Chapter 2.8 --- Drug release profile of nanoparticles --- p.61 / Chapter 2.9 --- MRI study of nanoparticles --- p.67 / Chapter 2.10 --- Conclusion --- p.69 / Chapter Chapter 3- --- Experimental Procedures / Chapter 3.1 --- General Information --- p.72 / Chapter 3.2 --- General procedure of synthesis of polyethers 3a-b --- p.73 / Chapter 3.2.1 --- Synthesis of 3a --- p.74 / Chapter 3.2.2 --- Synthesis of 3b --- p.74 / Chapter 3.3 --- General procedure of synthesis of diesters 4a-b --- p.75 / Chapter 3.3.1 --- Synthesis of 4a --- p.75 / Chapter 3.3.2 --- Synthesis of 4b --- p.76 / Chapter 3.4 --- General procedure of synthesis of dibenzo crown ether esters 5a-c --- p.77 / Chapter 3.4.1 --- Synthesis of 5a --- p.77 / Chapter 3.4.2 --- Synthesis of 5b --- p.78 / Chapter 3.4.3 --- Synthesis of 5c --- p.78 / Chapter 3.5 --- General procedure of synthesis of dibenzo-crown ethers la-c --- p.79 / Chapter 3.5.1 --- Synthesis of la --- p.80 / Chapter 3.5.2 --- Synthesis of lb --- p.80 / Chapter 3.5.3 --- Synthesis of lc --- p.81 / Chapter 3.6 --- Preparation of superparamagnetic Fe3O4 nanoparticle with an average diameter 120 nm --- p.81 / Chapter 3.7 --- Preparation of core/shell Fe3O4@SiO2 nanoparticle --- p.82 / Chapter 3.8 --- Preparation of Fe3O4@SiO2@meso(CTAB)-Si02 nanoparticle --- p.82 / Chapter 3.9 --- Preparation of Fe3O4@SiO2@meso(CTAB)-SiO2-NH2 nanoparticle --- p.83 / Chapter 3.10 --- Preparation of Fe3O4@SiO2@meso-SiO2@crown ether(a-c) nanoparticles --- p.83 / Chapter 3.11 --- Protocol of biological study of functionalized nanoparticles --- p.84 / Chapter 3.11.1 --- MTT protocol --- p.84 / Chapter 3.11.2 --- Cytotoxicity study --- p.84 / Chapter 3.11.3 --- Cell adhesion study --- p.85 / Chapter 3.11.4 --- Cell proliferation study --- p.85 / Chapter 3.11.5 --- Cellular uptake of functionalized nanoparticles --- p.85 / Chapter 3.12 --- Drug loading of functionalized nanoparticles --- p.86 / Chapter 3.13 --- Drug release profile of functionalized nanoparticles --- p.87 / Chapter 3.14 --- MRI study of nanoparticles --- p.87 / References --- p.89 / Appendix / List of Spectra --- p.A-1
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_327497 |
| Date | January 2011 |
| Contributors | Lee, Siu Fung., Chinese University of Hong Kong Graduate School. Division of Chemistry. |
| Source Sets | The Chinese University of Hong Kong |
| Language | English, Chinese |
| Detected Language | English |
| Type | Text, bibliography |
| Format | print, x, 91, A22 leaves : ill. ; 30 cm. |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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