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Protamine-heparin titration methods for the determination of circulating anti-coagulants

The hemorrhagic syndromes that occurred after atomic bomb irradiation (1) have attracted attention, because the phenomena did not seem to be fully explicable on the basis of thrombocytopenia alone. It was first suggested by Allen and Jacobson (2), that an excess of heparin in the blood might be the cause of the decreased coagulability and bleeding tendency after acute ionizing irradiation. Allen then developed a heparin-protamine titration test (3) tor the demonstration of heparin or heparin-like substances in the circulating blood.

Identiferoai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.122693
Date January 1950
CreatorsDe Leeuw, Nannie K.
ContributorsLowenstein, L. (Supervisor)
PublisherMcGill University
Source SetsLibrary and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada
LanguageEnglish
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
Formatapplication/pdf
CoverageMaster of Science. (Department of Experimental Medicine.)
RightsAll items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated.
RelationTheses scanned by McGill Library.

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