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Note: Page 57 missing in original / In October 1946 a dog was prepared in these laboratories with a large partially innervated gastric pouch. The pouch was a modification of the Cope operation (30), a pouch made from the lesser curvature of the stomach. The dog was standardized to the various gastric function tests and was maintained on a normal kennel diet of minced meat. Within 48 days the volume of gastric juice secreted by the pouch increased from an average of 50 c.c. to an average of 135 c. c. daily. There was also noted an increase in the amount of water taken and in the volume of urine excreted.

The hemorrhagic syndromes that occurred after atomic bomb irradiation (1) have attracted attention, because the phenomena did not seem to be fully explicable on the basis of thrombocytopenia alone. It was first suggested by Allen and Jacobson (2), that an excess of heparin in the blood might be the cause of the decreased coagulability and bleeding tendency after acute ionizing irradiation. Allen then developed a heparin-protamine titration test (3) tor the demonstration of heparin or heparin-like substances in the circulating blood.

Orthostasis, which involves changing from the recumbent to the upright posture, brings the considerable force of gravity to bear on the vascular bed. In man, the distance from the thorax to the mid thigh is approximately 90 cms. Thus a pressure head of 90 cms water develops in the thigh veins which, in recumbency, are distended by a pressure of, at most, 20 cms water. The thighs and buttocks can accomodate very considerable amounts of blood at such pressures.

The present investigation was carried out in a patient with the adrenogenital syndrome who was found to have an adrenal tumor. The urinary corticosteroids and 17-ketosteroids were studied during three different periods: before any treatment, on cortisone administration, and after surgical removal of the tumor.

These studies report attempts to induce ketosis in diabetic patients in order to obtain more information about fat and ketone metabolism in different clinical types of diabetes mellitus. All patients with diabetes mellitus have impaired ability to accelerate the metabolism of carbohydrate leading to varying degrees of hyperglycemia and glycosuria. As well as this abnormality in carbohydrate metabolism, there are abnormalities in fat and ketone metabolism which are different in the various clinical types of patients with diabetes mellitus. These studies were designed to quantitate some of these differences.

It is well known that since the advent of insulin and later the antibiotics, the acute complications of diabetes mellitis have become a remedial rarity and that the late vascular complications have assumed far greater prominance with regards both morbidity and mortality. Of these pathological changes only those that affect the retinal and glomerular capillaries can be considered unique for the diabetic subject. [...]

The continuous formation of antibodies over long periods of time after immunization of animals with certain toxoids and bacterial polysaccharide (1, 2), dextran and blood group substances (3), and viruses (4), is well documented. More recently, antibodies of the nonprecipitating type have been shown to persist in the circulation of rabbits following immunization with serum protein antigens (5). In a previous study, it was shown that the non-precipitating antibodies could not be differentiated from the precipitating antibodies on the basis of their electrophoretic, sedimentation and salting out properties (6), although it was demonstrated that they, unlike the precipitating type, could not sensitize guinea pigs to anaphylactic shock in vitro (7).