It is well known that not only histamine but also other smooth muscle stimulating substances play a role in the symptomatology of different types of allergic diseases. The substance most widely studied in this field is histamine which is responsible for a number of symptoms of allergic diseases. In the past 50 years, a great deal of work has been carried out to find new drugs which either prevent release of histamine or its action on smooth muscles and vessels. [...]

In spite of recent therapeutic strides in the treatment of the shock syndrome, there is still a high mortality rate. In recent years there have been more and more proponents of the idea that vasoconstrictors are not the ideal agents for the treatment of this syndrome and that one may be falsely secure when reading normotensive pressures on the sphymomanometer as this may not reflect the hemodynamic state of the patient as a whole. A few have rounded the circle and advocated the use of adrenergic blocking agents. [...]

Missing pages / It has been known for many centuries that the lymph nodes and spleen become enlarged during the course of certain diseases. References to buboes and swelling of the spleen can be found in the writings of Hippocrates (91). With the development of techniques which allowed the microscopic anatomy of lymphoid organs to be studied, the concept arose that the lymph nodes could act as filters to prevent toxic substances from entering the blood circulation (21,183). Quantitative measurements showed that lymph nodes were very efficient at filtering out baeteria injected into the afferent lymphatic vessels(56). [...]

Early workers in the field of pituitary cytology classified the cells of the anterior pituitary according to their staining abilities. Thus Wolfe and Cleveland, in 1933, using Orange G and aniline blue, divided the cell types in the anterior pituitary of the female rat into three groups [...]

Postprint attachments without IR clearance. / Ozone was discovered in 1840 by Charles Frederik Schonbein (1), Professer of Chemistry at the University of Basel, Switzerland, who communicated this discovery to the Basel Society for Natural History on April 8, 1840. The discovery appears in several publications during that year (2 - 5) including the British Association Reports, the latter publication being the first on the subject in English (5). [...]

The cardiorespiratory alterations accompanying hypoxia in man have been the object of much scientific study since Biot and Guy-Lussac in 1804 first observed an increase in pulse rate as they ascended to 4000 metres in a balloon. They correctly ascribed the phenomenon to oxygen lack. The data accumulated on the subject up to 1959 has been well reviewed by Korner (38) who points out that while it is possible to present a fairly clear picture of the gross circulatory changes accompanying hypoxia, the mechanisms of the control of the cardiorespiratory alterations remain unknown. [...]

Obesity is very common in the United States and Canada today. According to the Society of Actuaries Build and Blood Pressure Study (55), 20% of all males age 20 or over are more than 10% above their ideal weight, and 25% of females in the same age group are more than 10% overweight. 5% of all males and 11% of al1 females in this age group are more than 20% overweight. [...]

The history of the estrogenic hormones has its start at the turn of the century. In the year 1900, Knauer (1) showed that auto-transplanted ovaries in spayed animals could renew the estrous cycle. From this he concluded that the female gonads played an important part in the regulation of estrus and the production of ova and were thus organs of internal secretion. Thirteen years later, Fellner (2) showed that extracts of human placenta were potent in producing estrus in spayed animals; therefore the placenta was also involved in the metabolism of estrus-producing material. [...]

About 30 years ago, adipose tissue was considered to be metabolically inert. It was thought that its main functions were insulation of the body against heat loss and provision of mechanical support for certain organs. During the past 20 years, a surge of experimental work has changed these concepts radically. At the present time, adipose tissue is known to be the site of an intricate interplay of metabolic processes. [...]

Prometheus, creator of mankind, stole fire from the chariot of the sun and in defiance of the all-powerful Zeus gave it to mankind. Zeus, enraged, had Prometheus chained to a mountain pillar where greedy vultures tore at his liver all day, year in and year out. There was to be no end to Prometheus' punishment since each night his liver grew whole again (1). [...]