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Previous issue date: 2012-05-17 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico / Fucans is a name used for sulfated polysaccharides, which is most
characteristic structure of the presence of sulfated L-fucose, are found in brown
seaweed (Phaeophyceae) and echinoderms (sea urchins and sea cucumbers).
These polysaccharides have been reported to possess anticoagulant, antitumor,
anti-viral, anti-proliferative and anti-inflammatory activities. Therefore, in
the present study was evaluate the effect of the fucan from the brown seaweed
Spatoglossum schroederii in models of peritonitis and non-septic shock induced
by zymosan, as well as in a murine model of colitis induces by DSS. So, the
mice treatment by intravenous route with the fucan was able to reduce the
exudate formation and the cell migration in the model of acute peritonitis
induced by zymosan during the kinetic of 6, 24 and 48 hours. Similarly, in the
model of non-septic shock induced by zymosan the fucan demonstrated a
protector effect to inhibited the cellular migration to the peritoneo, to decrease
the levels of IL-6 in the serum and in the peritoneal exudate, to attenuate the
lose of weight in the mice; beside to reduce the serum levels of hepatic
transaminases and as well as the liver injury. In the model of murine colitis, the
treatment with the fucan reduced the lose of weight of the animals, decreased
the levels of IL-17 and IFN- produced in the gut and decrease the intestinal
lesion induced by DSS. In conclusion, the fucan used in this study presented a
significant protector effect in the murine models of inflammation / Fucana ? uma denomina??o utilizada para polissacar?deos sulfatados,
que tem como caracter?stica estrutural mais marcante a presen?a de L-fucose
sulfatada, sendo encontrados em algas pardas (Phaeophyceae) e em
equinodermos (ouri?os e pepinos do mar). Esses polissacar?deos tem sido
descritos por possuir atividade anticoagulante, anti-tumoral, anti-viral, antiproliferativa
e anti-inflamat?ria. Portanto, no presente estudo foi avaliado o
efeito da fucana da alga parda Spatoglossum schroederii em modelos de
peritonite e choque n?o s?ptico induzido por zimosan, bem como em um
modelo murino de colite induzida por DSS. Dessa forma, o tratamento de
camundongos pela via intravenosa com a fucana foi capaz de reduzir a
forma??o do exsudato e a migra??o celular no modelo de peritonite aguda
induzida por zimosan durante a cin?tica de 6, 24 e 48 horas. De maneira
semelhante, no modelo de choque n?o-s?ptico induzido por zimosan a fucana
demonstrou efeito protetor ao inibir a migra??o celular para o perit?nio, diminuir
os n?veis de IL-6 s?rico e no exsudato peritoneal, ao atenuar a perda de peso
do animais, al?m de reduzir os n?veis s?ricos das transaminases hep?ticas,
assim como a les?o no f?gado. No modelo murino de colite, o tratamento com a
fucana reduziu a perda de peso dos animais, diminuiu os n?veis de IL-17 e IFN-
produzidos no intestino e diminuiu a les?o intestinal ocasionada pela DSS.
Conclui-se ent?o, que a fucana usada nesse estudo apresentou efeito protetor
significativo diante dos modelos murinos de inflama??o
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/13084 |
| Date | 17 May 2012 |
| Creators | Silva, Ana Katarina Andrade |
| Contributors | CPF:61689858400, http://lattes.cnpq.br/6501426772186111, Guedes, Paulo Marcos da Matta, CPF:02351506731, http://lattes.cnpq.br/5445410844075357, Nascimento, George Jo?o Ferreira do, CPF:03356322460, http://lattes.cnpq.br/9194162897414436, Souto, Janeusa Trindade de |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Ci?ncias Biol?gicas, UFRN, BR, Biodiversidade; Biologia Estrutural e Funcional. |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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