<p> Objective: To identify genomic variance of C. difficile strains to determine diversity and transmission potential which can guide future directions in clinical care and hospital policy. Study Design: We analyzed epidemiological and genomic data from 35 patients with laboratory confirmed C. difficile infection (CDI) in two three-month periods in 2011 and 2014 at a large urban hospital. Whole genome sequencing was conducted on all isolates; further analysis was conducted for 13 cases of CDI with the highly virulent NAP1 strain. Results: Overall strain diversity within the hospital was analyzed. Stable prevalence among the NAP1 strain indicated an endemic status; no other strain exhibited a specific pattern. Genomic analysis identified at least 4 distinct subgroups in the NAP1 strain specific to the hospital. Conclusion: Genomic analysis is necessary to unequivocally identify C. difficile transmission and can provide both clinical and procedural benefit.</p>
| Identifer | oai:union.ndltd.org:PROQUEST/oai:pqdtoai.proquest.com:1606872 |
| Date | 23 January 2016 |
| Creators | Ciferri, Brianne |
| Publisher | Icahn School of Medicine at Mount Sinai |
| Source Sets | ProQuest.com |
| Language | English |
| Detected Language | English |
| Type | thesis |
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