Microbeam radiotherapy (MRT), an experimental high-dose rate concept with spatial
fractionation at the micrometre range, has shown a high therapeutic potential as well as good
preservation of normal tissue function in pre-clinical studies. We investigated the suitability of MRT
as a simultaneously integrated boost (SIB) in conventional whole-brain irradiation (WBRT). A 174 Gy
MRT SIB was administered with an array of quasi-parallel, 50 m wide microbeams spaced at a
centre-to-centre distance of 400 m either on the first or last day of a 5 4 Gy radiotherapy schedule
in healthy adult C57 BL/6J mice and in F98 glioma cell cultures. The animals were observed for signs
of intracranial pressure and focal neurologic signs. Colony counts were conducted in F98 glioma cell
cultures. No signs of acute adverse effects were observed in any of the irradiated animals within
3 days after the last irradiation fraction. The tumoricidal effect on F98 cell in vitro was higher when
the MRT boost was delivered on the first day of the irradiation course, as opposed to the last day.
Therefore, the MRT SIB should be integrated into a clinical radiotherapy schedule as early as possible.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:89486 |
| Date | 02 February 2024 |
| Creators | Jaekel, Felix, Bräuer-Krisch, Elke, Bartzsch, Stefan, Laissue, Jean, Blattmann, Hans, Scholz, Marten, Soloviova, Julia, Hildebrandt, Guido, Schültke, Elisabeth |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 8319 |
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