Throughout history, cancer has been severely plaguing mankind; the search for a
cure to cancer had long been sought by scientists and still poses as one of the
greatest challenges scientists have yet to overcome. Hypoxia in cells is a condition
where there is little to no oxygen availability in its environment. In general, this event
is detrimental since this can lead to cell necrosis or reoxygenation injuries. However,
hypoxia, a prominent property of most solid tumors, activates the hypoxia-inducible
factor (HIF-1) family of transcription factors that promotes angiogenesis. In this
study, we describe the design and synthesis of small-molecule inhibitors of the HIF-1
pathway.
| Identifer | oai:union.ndltd.org:GEORGIA/oai:scholarworks.gsu.edu:chemistry_theses-1061 |
| Date | 12 August 2014 |
| Creators | De Los Santos, Zeus Allen O. |
| Publisher | ScholarWorks @ Georgia State University |
| Source Sets | Georgia State University |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | Chemistry Theses |
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