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Design and Synthesis of Small-molecule Inhibitors of the Hypoxia Inducible Factor-1 as Anticancer Therapeutics

Throughout history, cancer has been severely plaguing mankind; the search for a
cure to cancer had long been sought by scientists and still poses as one of the
greatest challenges scientists have yet to overcome. Hypoxia in cells is a condition
where there is little to no oxygen availability in its environment. In general, this event
is detrimental since this can lead to cell necrosis or reoxygenation injuries. However,
hypoxia, a prominent property of most solid tumors, activates the hypoxia-inducible
factor (HIF-1) family of transcription factors that promotes angiogenesis. In this
study, we describe the design and synthesis of small-molecule inhibitors of the HIF-1
pathway.

Identiferoai:union.ndltd.org:GEORGIA/oai:scholarworks.gsu.edu:chemistry_theses-1061
Date12 August 2014
CreatorsDe Los Santos, Zeus Allen O.
PublisherScholarWorks @ Georgia State University
Source SetsGeorgia State University
Detected LanguageEnglish
Typetext
Formatapplication/pdf
SourceChemistry Theses

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