Graft-versus-host disease (GvHD) is a major complication
after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and is
highly influenced by the degree of HLA matching between recipient and
donor. The HLA-class Ib molecule HLA-G has been shown to promote tolerogenicity
through its interaction with inhibitory receptors found on several
immunocompetent cells. We hypothesized that in an allo-HSCT setting,
HLA-G mismatches may negatively impact the HLA-G-mediated tolerogenicity
either due to inefficient interaction with the inhibitory receptors of the
transplanted immune cells or due to direct allorecognition of mismatched
HLA-G on host cells by the immune cells of the donor.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:92835 |
| Date | 30 July 2024 |
| Creators | Neuchel, Christine, Gowdavally, Sowmya, Tsamadou, Chrysanthi, Platzbecker, Uwe, Sala, Elisa, Wagner-Drouet, Eva, Valerius, Thomas, Kröger, Nicolaus, Wulf, Gerald, Einsele, Hermann, Thurner, Lorenz, Schaefer-Eckart, Kerstin, Freitag, Sebastian, Casper, Jochen, Dürholt, Mareike, Kaufmann, Martin, Hertenstein, Bernd, Klein, Stefan, Ringhoffer, Mark, Frank, Sandra, Amann, Elisa Maria, Rode, Immanuel, Schrezenmeier, Hubert, Mytilineos, Joannis, Fürst, Daniel |
| Publisher | Wiley |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2059-2302, 2059-2310, 10.1111/tan.14733 |
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