Functional Genomics Approaches to Identify and Characterize Oncogenic Signaling

Description

Oncogenes drive cancer by hijacking normal cellular functions involved in proliferation and survival. Suppression of the driving oncogene is highly effective for promoting tumor regression, a phenomenon termed "oncogenic addiction." By using unbiased genetic tools to functionally probe oncogenic addiction, we can identify cancer dependencies and characterize aspects of oncogenic signaling.

Links & Downloads

1. Shao, Diane Donghui. 2013. Functional Genomics Approaches to Identify and Characterize Oncogenic Signaling. Doctoral dissertation, Harvard University.
2. http://dissertations.umi.com/gsas.harvard:11076
3. http://nrs.harvard.edu/urn-3:HUL.InstRepos:11169824

Tags

Cellular biology

Genetics

ATARiS

HNF1B

RAS

RNAi

YAP

Additional Fields

Identifer	oai:union.ndltd.org:harvard.edu/oai:dash.harvard.edu:1/11169824
Date	10 October 2015
Creators	Shao, Diane Donghui
Contributors	Hahn, William C.
Publisher	Harvard University
Source Sets	Harvard University
Language	en_US
Detected Language	English
Type	Thesis or Dissertation
Rights	open