Background: Effective interventions for maltreated children are impeded by gaps in our knowledge of the etiopathogenic mechanisms leading from maltreatment to mental disorders. Although some studies have already identified individual risk factors, there is a lack of large-scale multilevel research on how psychosocial, neurobiological, and genetic factors act in concert to modulate risk of internalizing psychopathology in childhood following maltreatment. To help close this gap, we aim to delineate gender-specific pathways from maltreatment to psychological disorder/resilience. To this end, we examine the interplay of specific maltreatment characteristics and psychological, endocrine, metabolomic,
and (epi-)genomic stress response patterns as well as cognitive-emotional/social processes as determinants of developmental outcome. Specifically, we will explore endocrine, metabolomic, and epigenetic mechanisms leading from maltreatment to a higher risk of depression and anxiety disorders.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa.de:bsz:15-qucosa-171688 |
| Date | 10 June 2015 |
| Creators | White, Lars O., Klein, Annette M., Kirschbaum, Clemens, Kurz-Adam, Maria, Uhr, Manfred, Müller-Myhsok, Bertram, Hoffmann, Katrin, Sierau, Susan, Michel, Andrea, Stalder, Tobias, Horlich, Jenny, Keil, Jan, Andreas, Anna, Resch, Leonhard, Binser, Martin J., Costa, Anna, Giourges, Elena, Neudecker, Eva, Wolf, Christiane, Scheuer, Sandra, Ising, Marcus, Klitzing, Kai von |
| Contributors | Universitätsklinikum Leipzig, Klinik für Psychiatrie, Psychotherapie und Psychosomatik des Kindes/Jugendalters, Technische Universität Dresden, Fachrichtung Psychologie, Stadtjugendamt München,, Amt für Jugend, Familie und Bildung Leipzig,, Max-Planck-Institut für Psychiatrie ,, Ludwig-Maximilians-Universität München, Munich Cluster for Systems Neurology (SyNergy), University of Liverpool, Institute of Translational Medicine, BioMed Central,, Springer, |
| Publisher | Universitätsbibliothek Leipzig |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | doc-type:article |
| Format | application/pdf |
| Source | BMC psychiatry 2015, 15 (126) |
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