The pharmacokinetics of verapamil were evaluated in the young and elderly after steady state administration of a sustained release formulation. The objective was to determine whether the interindividual metabolic variability of verapamil and its main metabolites could be correlated with the enzymatic activity of CYP3A4 by using dextromethorphan (DM) as an in vivo probe of CYP3A4 activity. / Pharmacokinetic analysis showed a significant age related increase in the clearance of verapamil. Verapamil interindividual variability could not be correlated with formation of 3-methoxy-morphinan. Our results suggest that verapamil metabolism may be significantly mediated by other cytochromes.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.20239 |
| Date | January 1997 |
| Creators | Anacleto, Ana Isabel. |
| Contributors | Wainer, Irving (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Pharmacology & Therapeutics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001604953, proquestno: MQ44115, Theses scanned by UMI/ProQuest. |
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