Objective: To identify predictors of change in the physical and mental components of HRQOL following two chemotherapy cycles in patients with advanced NSCLC Methods: A secondary analysis of data on 47 subjects with advanced NSCLC before and after receiving two cycles of first-line chemotherapy was performed, using multiple linear regression. Predictors were pre-chemotherapy 6-Minute Walk Test (6MWT) distance, grip strength, one-minute chair rise repetitions, Schwartz Cancer Fatigue Scale (SCFS) score, Lung Cancer Subscale score and Patient-Generated Subjective Global Assessment score. Outcomes were change in the physical and mental component summaries (PCS and MCS) of the 36-item Short-Form Health Survey. Results: Adjusted for age, gender and chemotherapy combination, pre-chemotherapy SCFS score and 6MWT distance significantly predicted change in MCS score (p<0.01). No significant predictors were found for PCS change. Conclusion: Clinical management of fatigue and physical function may be useful for HRQOL optimization in patients with advanced NSCLC undergoing chemotherapy. / But: Identifier les facteurs prédisposant au changement en QV pendant la chimiothérapie aux patients atteints de CPSA Méthodologie: Une analyse secondaire des données sur 47 sujets avec le CPSA avant et après deux cycles de chimiothérapie était exécutée en utilisant la régression linéaire multiple. Les variables étaient le test de marche de 6-minutes (TM6), la force de préhension, les levés de la chaise, les scores Schwartz Cancer Fatigue Scale (SCFS), les scores Lung Cancer Subscale et les scores Patient-Generated Subjective Global Assessment avant chimiothérapie et changement en scores résumés psychiques (MCS) et physiques (PCS) du SF-36 après chimiothérapie. Résultats: Ajustés pour l'âge, le sexe et la combinaison de chimiothérapie, les SCFS et TM6 avant chimiothérapie prédisposaient significativement au changement de score MCS (p<0.01). Aucune variable n'était significative pour changement de score PCS. Conclusion: La gestion clinique de la fatigue et la fonction physique serait utile pour ces patients.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.95076 |
| Date | January 2010 |
| Creators | Shallwani, Shirin |
| Contributors | Jadranka Spahija (Internal/Cosupervisor2), Maureen Simmonds (Internal/Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | French |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (School of Physical & Occupational Therapy) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | Electronically-submitted theses. |
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