The regulation of surface tension (ST) by surfactants plays an important role in the human
respiratory system but is largely unexplored in brain homeostasis. The aim of this study was to
evaluate changes in ST in relation to surfactant proteins (SPs) in children with intraventricular
hemorrhage (IVH). CSF samples from 93 patients were analyzed for ST with a force tensiometer
and SP-A-D and -G with ELISA assays. Patients belonged to six groups: (i) IVH before primary
intervention (PI), (ii) IVH 4–28 days after PI, (iii) IVH 44–357 days after PI, (iv) hydrocephalus,
(v) sepsis and (vi) controls. We found indirect correlations and significant differences in ST and SPs
(all p < 0.001; except for SP-C, p = 0.007). Post hoc analyses showed significantly decreased ST in
IVH patients before PI compared with patients with hydrocephalus, sepsis or controls (p < 0.001),
but it increased in IVH patients over time. All SPs were significantly elevated when comparing IVH
patients before PI with controls (all p < 0.001; except for SP-C, p = 0.003). Children suffering from IVH
displayed an increase in SPs and a decrease in ST as coping mechanisms to preserve CSF flow. The
increase in ST over time could serve as prognostic marker for the healing process.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:91344 |
| Date | 13 May 2024 |
| Creators | Reger, Rieka M., Meinicke, Anton, Härtig, Wolfgang, Knüpfer, Matthias, Thome, Ulrich, Schob, Stefan, Krause, Matthias |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1440 |
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