Previous studies reported on the broad-spectrum antiviral function of heparin. Here we
investigated the antiviral function of magnesium-modified heparin and found that modified heparin
displayed a significantly enhanced antiviral function against human adenovirus (HAdV) in immortalized
and primary cells. Nuclear magnetic resonance analyses revealed a conformational change
of heparin when complexed with magnesium. To broadly explore this discovery, we tested the
antiviral function of modified heparin against herpes simplex virus type 1 (HSV-1) and found that the
replication of HSV-1 was even further decreased compared to aciclovir. Moreover, we investigated the
antiviral effect against the new severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2)
and measured a 55-fold decreased viral load in the supernatant of infected cells associated with a
38-fold decrease in virus growth. The advantage of our modified heparin is an increased antiviral
effect compared to regular heparin.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:89172 |
| Date | 22 January 2024 |
| Creators | Mese, Kemal, Bunz, Oskar, Volkwein, Wolfram, Vemulapalli, Sahithya P.B., Zhang, Wenli, Schellhorn, Sebastian, Heenemann, Kristin, Rueckner, Antje, Sing, Andreas, Vahlenkamp, Thomas W., Severing, Anna-Lena, Gao, Jian, Aydin, Malik, Jung, Dominik, Bachmann, Hagen S., Zänker, Kurt S., Busch, Ulrich, Baiker, Armin, Griesinger, Christian, Ehrhardt, Anja |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 10075 |
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