The effects of short-term hyperoxia on age-related diseases and aging biomarkers have
been reported in animal and human experiments using different protocols; however, the
findings of the studies remain conflicting. In this systematic review, we summarized the
existing reports in the effects of short-term hyperoxia on age-related diseases, hypoxiainducible
factor 1α (HIF-1α), and other oxygen-sensitive transcription factors relevant to
aging, telomere length, cellular senescence, and its side effects. This review was done as
described in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses
(PRISMA) guideline. A systematic search was done in PubMed, Google Scholar, and
Cochrane Library and from the references of selected articles to identify relevant studies
until May 2021. Of the total 1,699 identified studies, 17 were included in this review. Most
of the studies have shown significant effects of short-term hyperoxia on age-related
diseases and aging biomarkers. The findings of the studies suggest the potential benefits
of short-term hyperoxia in several clinical applications such as for patients undergoing
stressful operations, restoration of cognitive function, and the treatment of severe
traumatic brain injury. Short-term hyperoxia has significant effects in upregulation or
downregulation of transcription factors relevant to aging such as HIF-1α, nuclear factor
kappa-light-chain-enhancer of activated B-cells (NF-kB), and nuclear factor (erythroidderived
2)-like 2 (NRF2) among others. Short-term hyperoxia also has significant effects to
increase antioxidant enzymes, and increase telomere length and clearance of senescent
cells. Some of the studies have also reported adverse consequences including
mitochondrial DNA damage and nuclear cataract formation depending on the dose
and duration of oxygen exposure. In conclusion, short-term hyperoxia could be a
feasible treatment option to treat age-related disease and to slow aging because of its
ability to increase antioxidant enzymes, significantly increase telomere length and
clearance of senescent cells, and improve cognitive function, among others. The
reported side effects of hyperoxia vary depending on the dose and duration of
exposure. Therefore, it seems that additional studies for better understanding the
beneficial effects of short-term hyperoxia and for minimizing side effects are necessary
for optimal clinical application.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:89185 |
| Date | 22 January 2024 |
| Creators | Tessema, Belay, Sack, Ulrich, Serebrovska, Zoya, König, Brigitte, Egorov, Egor |
| Publisher | Frontiers Media S.A. |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 783144 |
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