In recent years, the impressive progress performed in imaging, computational and technological fields have made possible the emergence of image-guided radiation therapy (IGRT) and adaptive radiation therapy (ART). The accuracy in radiation dose delivery reached by IMRT offers the possibility to increase locoregional dose-intensity, potentially overcoming the poor tumor control achieved by standard approaches. However, before implementing such a technique in clinical routine, a particular attention has to be paid at the target volumes definition and delineation procedures to avoid inadequate dosage to TVs/OARs.
In head and neck squamous cell carcinoma (HNSCC), the GTV is typically defined on CT acquired prior to treatment. However, providing functional information about the tumor, FDG-PET might advantageously complete the classical CT-Scan to better define the TVs. Similarly, re-imaging the tumor with optimal imaging modality might account for the constantly changing anatomy and tumor shape occurring during the course of fractionated radiotherapy. Integrating this information into the treatment planning might ultimately lead to a much tighter dose distribution.
From a methodological point of view, the delineation of TVs on anatomical or functional images is not a trivial task. Firstly, the poor soft tissue contrast provided by CT comes out of large interobserver variability in GTV delineation. In this regard, we showed that the use of consistent delineation guidelines significantly improved consistency between observers, either with CT and with MRI. Secondly, the intrinsic characteristics of PET images, including the blur effect and the high level of noise, make the detection of the tumor edges arduous. In this context, we developed specific image restoration tools, i.e. edge-preserving filters for denoising, and deconvolution algorithms for deblurring. This procedure restores the image quality, allowing the use of gradient-based segmentation techniques. This method was validated on phantom and patient images, and proved to be more accurate and reliable than threshold-based methods.
Using these segmentation methods, we proved that GTVs significantly shrunk during radiotherapy in patients with HNSCC, whatever the imaging modality used (MRI, CT, FDG-PET). No clinically significant difference was found between CT and MRI, while FDG-PET provided significantly smaller volumes than those based on anatomical imaging. Refining the target volume delineation by means of functional and sequential imaging ultimately led to more optimal dose distribution to TVs with subsequent soft tissue sparing.
In conclusion, we demonstrated that a multi-modality-based adaptive planning is feasible in HN tumors and potentially opens new avenues for dose escalation strategies. As a high level of accuracy is required by such approach, the delineation of TVs however requires a special care.
| Identifer | oai:union.ndltd.org:BICfB/oai:ucl.ac.be:ETDUCL:BelnUcetd-04232008-130552 |
| Date | 28 April 2008 |
| Creators | Geets, Xavier |
| Publisher | Universite catholique de Louvain |
| Source Sets | Bibliothèque interuniversitaire de la Communauté française de Belgique |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://edoc.bib.ucl.ac.be:81/ETD-db/collection/available/BelnUcetd-04232008-130552/ |
| Rights | unrestricted, J'accepte que le texte de la thèse (ci-après l'oeuvre), sous réserve des parties couvertes par la confidentialité, soit publié dans le recueil électronique des thèses UCL. A cette fin, je donne licence à l'UCL : - le droit de fixer et de reproduire l'oeuvre sur support électronique : logiciel ETD/db - le droit de communiquer l'oeuvre au public Cette licence, gratuite et non exclusive, est valable pour toute la durée de la propriété littéraire et artistique, y compris ses éventuelles prolongations, et pour le monde entier. Je conserve tous les autres droits pour la reproduction et la communication de la thèse, ainsi que le droit de l'utiliser dans de futurs travaux. Je certifie avoir obtenu, conformément à la législation sur le droit d'auteur et aux exigences du droit à l'image, toutes les autorisations nécessaires à la reproduction dans ma thèse d'images, de textes, et/ou de toute oeuvre protégés par le droit d'auteur, et avoir obtenu les autorisations nécessaires à leur communication à des tiers. Au cas où un tiers est titulaire d'un droit de propriété intellectuelle sur tout ou partie de ma thèse, je certifie avoir obtenu son autorisation écrite pour l'exercice des droits mentionnés ci-dessus. |
Page generated in 0.0027 seconds