Objective: IGF1 is associated with metabolic parameters and involved in glucose metabolism. Low-IGF1 has been implicated in the etiology of glucose intolerance and subjects with pathological causes of either low- or high-IGF1 are at risk of diabetes. We hypothesized that both low- and high-IGF1 levels increase the risk of diabetes and aimed to assess the role of IGF1 in the risk of developing diabetes in a large prospective study.
Design: An analysis of two prospective cohort studies, the DETECT study and SHIP.
Methods: We measured IGF1 levels in 7777 nondiabetic subjects and assessed incident diabetes mellitus during follow-up.
Results: There were 464 cases of incident diabetes during 32 229 person-years (time of follow-up in the DETECT study and SHIP: 4.5 and 5 years respectively). There was no heterogeneity between both studies (P>0.4). The hazard ratios (HRs) of incident diabetes in subjects with IGF1 levels below the 10th or above the 90th age- and sex-specific percentile, compared to subjects with intermediate IGF1 levels, were 1.44 (95% confidence interval (CI) 1.07–1.94) and 1.55 (95% CI 1.06–2.06) respectively, after multiple adjustment. After further adjustment for metabolic parameters, the HR for low-IGF1 became insignificant. Analysis of IGF1 quintiles revealed a U-shaped association of IGF1 with risk of diabetes. Results remained similar after exclusion of patients with onset of new diabetes within 1 year or with borderline glucose or HbA1c levels at baseline.
Conclusions: Subjects with low- or high-IGF1 level are at increased risk of developing diabetes.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:26329 |
| Date | January 2011 |
| Creators | Schneider, Harald Jörn, Friedrich, Nele, Klotsche, Jens, Schipf, Sabine, Nauck, Matthias, Völzke, Henry, Sievers, Caroline, Pieper, Lars, März, Winfried, Wittchen, Hans-Ulrich, Stalla, Günter Karl, Wallaschofski, Henri |
| Publisher | BioScientifica |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Source | European Journal of Endocrinology, 2011, Bd. 164, S. 223-229, ISSN: 0804-4643 |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 10.1530/EJE-10-0963, 0804-4643 |
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