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Previous issue date: 2006 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / The development of a Th1 immune response is the key event to prevent Leishmania
infection and is linked with the IL-12 production by monocytes, dendritic cells,
macrophages and neutrophils. The IL-12 signal induces the increase of IFN-γ
production by T cells, favoring the profile of the Th1 immune response and the
resistance phenotype to the infection. In the vertebrate host, the leishmania inhabits in
cells of the mononuclear phagocyte system (MPS), which is also responsible for the
elimination of the parasite. The participation of immature cells of MPS in the initial
production of IL-12 has been discussed. It was demonstrated recently that a
population of mononuclear phagocytes, derived from bone marrow culture and
expressing the marker ER-HR3 produced great amount of IL-12p40 after stimulation in
vitro with procyclic or metacyclic promastigotes of L. (L.) major. The initial production
of IL-12 by MPS cells is under investigation. It is unclear the role of mononuclear
phagocytes, in different stages of maturation, in the production of
IL-12p40 in vivo. In this work, we evaluated the involvement of MPS cells, in different
stage of maturation, with the IL-12p40 production in vivo in draining lymph nodes of
BALB/c mice after 48 h of infection with L. (L.) major. Our results showed that CD31+
cells (mononuclear phagocytes precursors) were absent in the draining lymph nodes
of the subcutaneously footpad injection and that the number of ER-MP58+
(immature mononuclear phagocytes), ER-HR3+ cells (mononuclear phagocytes in the intermediate stage of maturation) and 33D1+
(mature phagocytes) increase in the period of 48 h after infection. We showed, also, that ER-MP58+
responsible for great part of the draining lymph nodes IL-12 production 48 h after
infection with stationary-phase promastigotes of L. (L.) major in mice BALB/c. We
suggested that, in vivo, the ER-MP58+ population, together with other cellular
populations, known as IL-12 producers, ER-MP58+ cell has an important role in the inflammation induced by the parasitic inoculum. / O desenvolvimento de uma resposta imune do tipo Th1 é o evento chave para
prevenir a infecção murina por Leishmania e está interligada à produção de IL-12 por
monócitos, células dendríticas, macrófagos e neutrófilos. A sinalização via IL-12
aumenta a produção de IFN-γ por células T, favorecendo o perfil Th1 da resposta
imune e o fenótipo de resistência à infecção. A leishmania, no hospedeiro vertebrado,
reside em células do sistema fagocítico mononuclear (SFM), o qual também é
responsável pela eliminação do parasito. A participação de células indiferenciadas do
SFM na produção de IL-12 vem sendo discutida. Foi demonstrado recentemente que
uma população de fagócitos mononucleares, derivados de cultura de medula óssea e
expressando o marcador ER-HR3 produzia grande quantidade de IL-12p40 após
estimulação in vitro com formas procíclicas ou metacíclicas de L. (L.) major. A
produção de IL-12 na infecção por L. (L.) major por fagócitos em diferentes estágios
de maturação in vivo ainda não está claro. Neste trabalho, avaliamos o envolvimento
de células em diferentes estágios de maturação em linfonodos drenantes após 48 h
de infecção por L. (L.) major em camundongos BALB/c, quanto à produção de IL-
12p40. Verificamos que células CD31+ (precursores de fagócitos mononucleares)
estão ausentes nos linfonodos drenantes do sítio do inóculo e que o número de células ER-HR3+ (fagócitos mononucleares em estágio intermediário de maturação), células ER-MP58+ (fagócitos imaturos) e 33D1+ (subpopulações de células dendríticas) aumenta no período de 48 h após a infecção. Mostramos também que,
células ER-MP58+ são as principais responsáveis por grande parte da produção de
IL-12 nos linfonodos drenantes 48 h após a infecção por L. (L.) major em
camundongos BALB/c. Sugerimos que, in vivo, a população ER-MP58+
com as outras populações celulares, conhecidas como produtoras de IL-12, têm um
papel relevante na inflamação induzida pelo inóculo parasitário.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.bc.ufg.br:tde/2879 |
| Date | January 2006 |
| Creators | Cardoso, Ludimila Paula Vaz |
| Contributors | Oliveira, Milton Adriano Pelli de, Lima, Glória Maria Collet de Araújo |
| Publisher | Universidade Federal de Goiás, Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP), UFG, Brasil, Faculdade de Medicina - FM (RG) |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFG, instname:Universidade Federal de Goiás, instacron:UFG |
| Rights | http://creativecommons.org/licenses/by-nc-nd/4.0/, info:eu-repo/semantics/openAccess |
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