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Formation of Dicentric and Acentric Chromosomes, by a Template Switch Mechanism, in Budding Yeast

Chromosomal rearrangements occur in all organisms and are important both in the evolution of species and in pathology. In this dissertation I show that in Saccharomyces cerevisiae, or budding yeast, one type of chromosomal rearrangement occurs when inverted repeats fuse, likely during DNA replication by a novel mechanism termed "faulty template switching". This fusion can lead to the formation of either a dicentric or acentric chromosome, depending on the direction of the replication fork. Dicentric chromosomes are inherently unstable due to their abnormal number of centromeres, and thus undergo additional chromosomal rearrangements and chromosome loss.

Identiferoai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/194260
Date January 2010
CreatorsPaek, Andrew Luther
ContributorsWeinert, Ted, Weinert, Ted, Dixon, Kathleen, Little, John, Nagy, Lisa
PublisherThe University of Arizona.
Source SetsUniversity of Arizona
LanguageEnglish
Detected LanguageEnglish
Typetext, Electronic Dissertation
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.

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