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Previous issue date: 2009-03-27 / Ferritin is a protein composed of heavy and light chains, non-covalently linked and which accommodates, in its core, thousands of atoms of iron. Furthermore, this protein represents the stock of iron in the body and it is characterized as an acute marker and predictor of diseases, such as iron deficiency anemia, hereditary hemochromatosis and others. Considering the variability of reference values and the analytical methods currently available, the aim of this work was to propose 95% confidence intervals for adults in the State of Rio Grande do Norte, Brazil, after determining the average concentration of serum ferritin for both sexes, beyond its correlation with the age. We analyzed 385 blood samples, collected by venipuncture from individuals residing in the State, after 12-14 hours of fast. The populational sample had 169 men and 216 women between 18-59 years old, which filled a questionnaire on socioeconomic, food habits and accounts about previous and current diseases. The sample collections were itinerant and the results of erythrogram, fasting glucose, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transferase, urea, creatinine, leukocyte count and platelets, beyond C-reactive protein, were issued to each participant, so that, after selection of the apparently healthy individuals, the dosage of serum ferritin was carried out. Statistical analysis was performed using the softwares SPSS 11.0 Windows version, Epi Info 3.3.2 and Graf instant pad (version 3.02), and the random population sample was single (finite population), for which the test of linear correlation and diagram of dispersion were also made. After selection of individuals and determination of serum ferritin, the most discrepant outliers were disregarded (N = 358, Men = 154/Women = 207) and the average value determined for the masculine sex individuals was 167,18 ng / dL; for the feminine sex individuals, the average value obtained was 81,55 ng / dL. Moreover, we found that 25% of men had values < 90,30 ng / dL; 50% ≤ 156,25 ng / dL and 75% ≤ 229,00 ng / dL. In the group of women, 25% had values < 38,80 ng / dL; 50% ≤ 65,00 ng / dL and 75% ≤ 119,00 ng / dL. Through the correlation coefficient (r = 0,23 with p = 0,003), it is possible to suggest the existence of positive linear correlation between age and serum ferritin for men. The correlation coefficient for women (r = 0,16 with p = 0,025) also confirms the existence of positive linear correlation between serum ferritin and age. Considering the analysis carried out and specific methods corroborating with the proposed benchmarks, we concluded that the average value found for men is higher than that found for women. Furthermore, this scenario rises with age for both sexes, and the 95% confidence intervals obtained were 74 ng/dL ≤ μ ≤ 89 ng/dL and 152ng/dL ≤ μ ≤183ng/dL for the feminine and masculine sex individuals respectively / A ferritina ? uma prote?na composta por cadeias leves e pesadas ligadas n?o- covalentemente e que acomoda, em seu n?cleo, milhares de ?tomos de ferro. Al?m disso, esta prote?na representa os estoques de ferro no organismo e caracteriza-se como marcador de fase aguda e preditor de doen?as como anemia por defici?ncia de ferro, hemocromatose heredit?ria, entre outras. Diante da variabilidade de valores de refer?ncia e m?todos anal?ticos dispon?veis atualmente, a presente pesquisa objetivou propor intervalos de refer?ncia com 95% de confian?a para adultos do Estado do Rio Grande do Norte, ap?s determina??o da concentra??o m?dia de ferritina s?rica para ambos os sexos, correlacionando-as tamb?m com a idade. Foram analisadas 385 amostras de sangue, coletadas ap?s 12-14 horas de jejum por venopun??o, de indiv?duos residentes no Estado, sendo 169 homens e 216 mulheres entre 18-59 anos, os quais responderam a um question?rio relacionado a aspectos s?cio-econ?micos, alimentares, hist?rico de doen?as anteriores e queixas atuais. A coleta teve car?ter itinerante, tendo sido emitidos a cada participante os resultados de eritrograma, glicose em jejum, alanina aminotransferase, aspartato aminotransferase, γ- glutamil transferase, ureia, creatinina, contagem de leuc?citos e plaquetas, al?m de prote?na C reativa de modo que, ap?s sele??o dos indiv?duos aparentemente saud?veis, foi feita a dosagem de ferritina s?rica. As an?lises estat?sticas foram realizadas utilizando-se os softwares SPSS Windows vers?o 11.0, Epi Info 3.3.2 e Graf pad instant (vers?o 3.02), sendo que a amostra populacional foi aleat?ria simples (popula??o finita) para a qual foi feito o teste de correla??o linear e diagrama de dispers?o. Ap?s a sele??o dos indiv?duos e determina??o da ferritina s?rica, os outliers mais discrepantes foram desconsiderados, obtendo-se um valor m?dio para os indiv?duos do sexo masculino de 167,18 ng/dL e, para os indiv?duos do sexo feminino de 81,55 ng/dL. Analisando os valores obtidos, temos que 25% dos homens apresentaram valores < 90,30 ng/dL; 50% ≤ 156,25 ng/dL e 75% ≤ 229,00 ng/dL. No grupo das mulheres, 25% apresentam valores < 38,80 ng/dL; 50% ≤ 65,00 ng/dL e 75% ≤119,00 ng/dL. Por meio do coeficiente de correla??o, r = 0,23, e p = 0,003, ? poss?vel confirmar a exist?ncia de correla??o linear positiva entre idade e ferritina s?rica dos indiv?duos do sexo masculino, assim como o coeficiente de correla??o r = 0,16 e p = 0,025 confirma a exist?ncia de correla??o linear positiva entre a ferritina s?rica e a idade das mulheres. Diante das an?lises realizadas e corroborando com m?todos espec?ficos para proposi??o de valores de refer?ncia, conclu?mos que o valor m?dio encontrado para homens ? superior ao valor m?dio encontrado para mulheres, elevando-se com a idade para os indiv?duos de ambos os sexos. Al?m disso, os intervalos de refer?ncia determinados com 95% de confian?a, foram de 74 ng/dL ≤ μ ≤ 89 ng/dL e de 152 ng/dL ≤ μ ≤ 183 ng/dL, para os indiv?duos dos sexos feminino e masculino, respectivamente
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/13445 |
| Date | 27 March 2009 |
| Creators | Saldanha, Valdjane |
| Contributors | CPF:47015578042, http://lattes.cnpq.br/4311626091295357, Cavalcanti J?nior, Geraldo Barroso, CPF:10861203453, http://lattes.cnpq.br/0091662650633339, Cavagis, Alexandre Donizeti Martins, CPF:12369841885, http://lattes.cnpq.br/0907530041669620, Lemos, Telma Maria Araujo Moura |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Ci?ncias Farmac?uticas, UFRN, BR, Bioan?lises e Medicamentos |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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