A study was made with the objectives:
1. Evaluation of a micro-adsorption detector for use in liquid chromatography.
2. Evaluation of a micro-adsorption detector for use in gas ch.ranatography.
3. Investigation of the micro-adsorption cell as a tool for screening chromatographic systems, in adsorption studies, and as a micro-calorimeter.
The micro-adsorption detector was found to have sufficient sensitivity to detect nanogram quantities of a component in either a liquid or gaseous carrier, and to have a linear dynamic range of 10²-10³. These qualities, combined with the selectivity of the detector indicate its usefulness in both liquid and gas chromatographic operations. The major limitation to its use is the characteristic adsorption/desorption responsive curve, which requires increased column lengths or resolution over other detectors such as the UV detector. In addition a semi-quantitative correlation between MAD response and chromatographic retention times indicates that the detector has significant potential as a screening tool for separation systems. By means of a calibration apparatus the detector response was characterized in terms of heat flux and temperature differential, and heats of absorption were calculated at concentrations of 10⁻⁴- 10⁻⁶ molar. These compared favorably with those literature values which were available close to these concentrations. / Ph. D.
| Identifer | oai:union.ndltd.org:VTETD/oai:vtechworks.lib.vt.edu:10919/91013 |
| Date | January 1971 |
| Creators | Stafford, David Todd |
| Contributors | Chemistry |
| Publisher | Virginia Polytechnic Institute and State University |
| Source Sets | Virginia Tech Theses and Dissertation |
| Language | English |
| Detected Language | English |
| Type | Dissertation, Text |
| Format | vii, 106 leaves, application/pdf, application/pdf |
| Rights | In Copyright, http://rightsstatements.org/vocab/InC/1.0/ |
| Relation | OCLC# 34178115 |
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